Von Hippel-Lindau disease. Histopathologic findings in a treated and an untreated eye

Morton F Goldberg, James R. Duke

Research output: Contribution to journalArticle

Abstract

Both eyes from a patient with the von Hippel-Lindau syndrome were obtained for histologic examination. Angiomatosis retinae and retinal detachments were found bilaterally. The right eye, in which the lesion had been photocoagulated on two occasions, was studied by the conventional serial section technique. The effects of the light coagulation and the degree of preservation of the retinal angioma are described. The angioma consisted of proliferating endothelial cells and new-formed capillaries. Reactive gliosis was confined to the periphery of the lesion. The retinal vasculature of the untreated left eye was studied by the trypsin digestionflat mount technique. This demonstrated a large dilated arteriole extending to the far periphery, where it entered a contorted angioma composed of endothelial cells. From this, a dilated tortuous venule extended back to the posterior pole. Unusual proliferative endothelial changes in the "feeding" arteriole are described. The possibility that the von Hippel lesion (angiomatosis retinae) is a hamartomatous malformation of an entire vascular unit-arteriole, capillary bed, and venule -is discussed.

Original languageEnglish (US)
Pages (from-to)693-705
Number of pages13
JournalAmerican Journal of Ophthalmology
Volume66
Issue number4
StatePublished - Oct 1968
Externally publishedYes

Fingerprint

von Hippel-Lindau Disease
Arterioles
Hemangioma
Venules
Endothelial Cells
Vascular Malformations
Gliosis
Light Coagulation
Retinal Detachment
Trypsin

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Von Hippel-Lindau disease. Histopathologic findings in a treated and an untreated eye. / Goldberg, Morton F; Duke, James R.

In: American Journal of Ophthalmology, Vol. 66, No. 4, 10.1968, p. 693-705.

Research output: Contribution to journalArticle

@article{0f574b33a09d4698884974fcb139df73,
title = "Von Hippel-Lindau disease. Histopathologic findings in a treated and an untreated eye",
abstract = "Both eyes from a patient with the von Hippel-Lindau syndrome were obtained for histologic examination. Angiomatosis retinae and retinal detachments were found bilaterally. The right eye, in which the lesion had been photocoagulated on two occasions, was studied by the conventional serial section technique. The effects of the light coagulation and the degree of preservation of the retinal angioma are described. The angioma consisted of proliferating endothelial cells and new-formed capillaries. Reactive gliosis was confined to the periphery of the lesion. The retinal vasculature of the untreated left eye was studied by the trypsin digestionflat mount technique. This demonstrated a large dilated arteriole extending to the far periphery, where it entered a contorted angioma composed of endothelial cells. From this, a dilated tortuous venule extended back to the posterior pole. Unusual proliferative endothelial changes in the {"}feeding{"} arteriole are described. The possibility that the von Hippel lesion (angiomatosis retinae) is a hamartomatous malformation of an entire vascular unit-arteriole, capillary bed, and venule -is discussed.",
author = "Goldberg, {Morton F} and Duke, {James R.}",
year = "1968",
month = "10",
language = "English (US)",
volume = "66",
pages = "693--705",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Von Hippel-Lindau disease. Histopathologic findings in a treated and an untreated eye

AU - Goldberg, Morton F

AU - Duke, James R.

PY - 1968/10

Y1 - 1968/10

N2 - Both eyes from a patient with the von Hippel-Lindau syndrome were obtained for histologic examination. Angiomatosis retinae and retinal detachments were found bilaterally. The right eye, in which the lesion had been photocoagulated on two occasions, was studied by the conventional serial section technique. The effects of the light coagulation and the degree of preservation of the retinal angioma are described. The angioma consisted of proliferating endothelial cells and new-formed capillaries. Reactive gliosis was confined to the periphery of the lesion. The retinal vasculature of the untreated left eye was studied by the trypsin digestionflat mount technique. This demonstrated a large dilated arteriole extending to the far periphery, where it entered a contorted angioma composed of endothelial cells. From this, a dilated tortuous venule extended back to the posterior pole. Unusual proliferative endothelial changes in the "feeding" arteriole are described. The possibility that the von Hippel lesion (angiomatosis retinae) is a hamartomatous malformation of an entire vascular unit-arteriole, capillary bed, and venule -is discussed.

AB - Both eyes from a patient with the von Hippel-Lindau syndrome were obtained for histologic examination. Angiomatosis retinae and retinal detachments were found bilaterally. The right eye, in which the lesion had been photocoagulated on two occasions, was studied by the conventional serial section technique. The effects of the light coagulation and the degree of preservation of the retinal angioma are described. The angioma consisted of proliferating endothelial cells and new-formed capillaries. Reactive gliosis was confined to the periphery of the lesion. The retinal vasculature of the untreated left eye was studied by the trypsin digestionflat mount technique. This demonstrated a large dilated arteriole extending to the far periphery, where it entered a contorted angioma composed of endothelial cells. From this, a dilated tortuous venule extended back to the posterior pole. Unusual proliferative endothelial changes in the "feeding" arteriole are described. The possibility that the von Hippel lesion (angiomatosis retinae) is a hamartomatous malformation of an entire vascular unit-arteriole, capillary bed, and venule -is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0014345995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014345995&partnerID=8YFLogxK

M3 - Article

C2 - 4891878

AN - SCOPUS:0014345995

VL - 66

SP - 693

EP - 705

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 4

ER -