Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate

Zainab Farzal, Jonathan Walsh, Gabriella Lopes de Rezende Barbosa, Carlton J. Zdanski, Stephanie D. Davis, Richard Superfine, Luiz A. Pimenta, Julia S. Kimbell, Amelia Fischer Drake

Research output: Contribution to journalArticle

Abstract

Objectives/Hypothesis: Children with cleft lip and palate (CLP) often suffer from nasal obstruction that may be related to effects on nasal volume. The objective of this study was to compare side:side volume ratios and nasal volume in patients with unilateral (UCLP) and bilateral (BCLP) clefts with age-matched controls. Study Design: Retrospective case-control study using three-dimensional (3D) nasal airway reconstructions. Methods: We analyzed 20 subjects (age range=7-12 years) with UCLP and BCLP from a regional craniofacial center who underwent cone beam computed tomography (CT) prior to alveolar grafting. Ten multislice CT images from age-matched controls were also analyzed. Mimics software (Materialise, Plymouth, MI) was used to create 3D reconstructions of the main nasal cavity and compute total and side-specific nasal volumes. Subjects imaged during active nasal cycling phases were excluded. Results: There was no statistically significant difference in affected:unaffected side volume ratios in UCLP (P=.48) or left:right ratios in BCLP (P=.25) when compared to left:right ratios in controls. Mean overall nasal volumes were 9,932±1,807, 7,097±2,596, and 6,715±2,115 mm3 for control, UCLP, and BCLP patients, respectively, with statistically significant volume decreases for both UCLP and BCLP subjects from controls (P

Original languageEnglish (US)
JournalLaryngoscope
DOIs
StateAccepted/In press - 2015
Externally publishedYes

Fingerprint

Nasal Cavity
Cleft Lip
Cleft Palate
Nose
Nasal Obstruction
Cone-Beam Computed Tomography
Multidetector Computed Tomography
Case-Control Studies
Software
Retrospective Studies

Keywords

  • Bilateral cleft lip and palate
  • Nasal volume
  • Unilateral cleft lip and palate

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Farzal, Z., Walsh, J., Lopes de Rezende Barbosa, G., Zdanski, C. J., Davis, S. D., Superfine, R., ... Drake, A. F. (Accepted/In press). Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate. Laryngoscope. https://doi.org/10.1002/lary.25543

Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate. / Farzal, Zainab; Walsh, Jonathan; Lopes de Rezende Barbosa, Gabriella; Zdanski, Carlton J.; Davis, Stephanie D.; Superfine, Richard; Pimenta, Luiz A.; Kimbell, Julia S.; Drake, Amelia Fischer.

In: Laryngoscope, 2015.

Research output: Contribution to journalArticle

Farzal, Z, Walsh, J, Lopes de Rezende Barbosa, G, Zdanski, CJ, Davis, SD, Superfine, R, Pimenta, LA, Kimbell, JS & Drake, AF 2015, 'Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate', Laryngoscope. https://doi.org/10.1002/lary.25543
Farzal, Zainab ; Walsh, Jonathan ; Lopes de Rezende Barbosa, Gabriella ; Zdanski, Carlton J. ; Davis, Stephanie D. ; Superfine, Richard ; Pimenta, Luiz A. ; Kimbell, Julia S. ; Drake, Amelia Fischer. / Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate. In: Laryngoscope. 2015.
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