TY - JOUR
T1 - Volumetric nasal cavity analysis in children with unilateral and bilateral cleft lip and palate
AU - Farzal, Zainab
AU - Walsh, Jonathan
AU - Lopes De Rezende Barbosa, Gabriella
AU - Zdanski, Carlton J.
AU - Davis, Stephanie D.
AU - Superfine, Richard
AU - Pimenta, Luiz A.
AU - Kimbell, Julia S.
AU - Drake, Amelia Fischer
N1 - Publisher Copyright:
© 2015 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Objectives/Hypothesis Children with cleft lip and palate (CLP) often suffer from nasal obstruction that may be related to effects on nasal volume. The objective of this study was to compare side:side volume ratios and nasal volume in patients with unilateral (UCLP) and bilateral (BCLP) clefts with age-matched controls. Study Design Retrospective case-control study using three-dimensional (3D) nasal airway reconstructions. Methods We analyzed 20 subjects (age range = 7-12 years) with UCLP and BCLP from a regional craniofacial center who underwent cone beam computed tomography (CT) prior to alveolar grafting. Ten multislice CT images from age-matched controls were also analyzed. Mimics software (Materialise, Plymouth, MI) was used to create 3D reconstructions of the main nasal cavity and compute total and side-specific nasal volumes. Subjects imaged during active nasal cycling phases were excluded. Results There was no statistically significant difference in affected:unaffected side volume ratios in UCLP (P =.48) or left:right ratios in BCLP (P =.25) when compared to left:right ratios in controls. Mean overall nasal volumes were 9,932 ± 1,807, 7,097 ± 2,596, and 6,715 ± 2,115 mm3 for control, UCLP, and BCLP patients, respectively, with statistically significant volume decreases for both UCLP and BCLP subjects from controls (P <.05). Conclusions This is the first study to analyze total nasal volumes in BCLP patients. Overall nasal volume is compromised in UCLP and BCLP by approximately 30%. Additionally, our finding of no major difference in side:side ratios in UCLP and BCLP compared to controls conflicts with pre-existing literature, likely due to exclusion of actively cycling scans and our measurement of the functional nasal cavity.
AB - Objectives/Hypothesis Children with cleft lip and palate (CLP) often suffer from nasal obstruction that may be related to effects on nasal volume. The objective of this study was to compare side:side volume ratios and nasal volume in patients with unilateral (UCLP) and bilateral (BCLP) clefts with age-matched controls. Study Design Retrospective case-control study using three-dimensional (3D) nasal airway reconstructions. Methods We analyzed 20 subjects (age range = 7-12 years) with UCLP and BCLP from a regional craniofacial center who underwent cone beam computed tomography (CT) prior to alveolar grafting. Ten multislice CT images from age-matched controls were also analyzed. Mimics software (Materialise, Plymouth, MI) was used to create 3D reconstructions of the main nasal cavity and compute total and side-specific nasal volumes. Subjects imaged during active nasal cycling phases were excluded. Results There was no statistically significant difference in affected:unaffected side volume ratios in UCLP (P =.48) or left:right ratios in BCLP (P =.25) when compared to left:right ratios in controls. Mean overall nasal volumes were 9,932 ± 1,807, 7,097 ± 2,596, and 6,715 ± 2,115 mm3 for control, UCLP, and BCLP patients, respectively, with statistically significant volume decreases for both UCLP and BCLP subjects from controls (P <.05). Conclusions This is the first study to analyze total nasal volumes in BCLP patients. Overall nasal volume is compromised in UCLP and BCLP by approximately 30%. Additionally, our finding of no major difference in side:side ratios in UCLP and BCLP compared to controls conflicts with pre-existing literature, likely due to exclusion of actively cycling scans and our measurement of the functional nasal cavity.
KW - Nasal volume
KW - bilateral cleft lip and palate
KW - unilateral cleft lip and palate
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U2 - 10.1002/lary.25543
DO - 10.1002/lary.25543
M3 - Article
C2 - 26267849
AN - SCOPUS:84939146838
SN - 0023-852X
VL - 126
SP - 1475
EP - 1480
JO - Laryngoscope
JF - Laryngoscope
IS - 6
ER -