Abstract
Background. To assess volumetric changes of human papillomavirus (HPV)-related lymph nodes (LN) before, during, and after a course of intensity-modulated radiation therapy (IMRT) ± chemotherapy. Methods. Each "pathologic" LN (≥1 cm) was contoured on the available diagnostic/planning CTs before, during each week, and after treatment. Results. Seventy-nine LNs in 50 patients were identified. Beyond the first week of treatment, 3 patterns of LN change were recorded: consistently shrinking LN (n = 33; 41.8%), inconsistently shrinking LN with temporary enlargement limited to the first week (n = 14; 17.7%), or also during the subsequent weeks (n = 32; 40.5%). Nodal density at planning is highly predictive of group assignment, with a larger mean density for consistently over inconsistently shrinking LNs (p =.009). Also, this grouping predicts the response at the end of treatment. Conclusion. HPV-related LN behavior during IMRT is extremely variable but somewhat predictable on the basis of nodal density at planning.
Original language | English (US) |
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Pages (from-to) | 1640-1647 |
Number of pages | 8 |
Journal | Head and Neck |
Volume | 34 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2012 |
Keywords
- IMRT
- lymph nodes
- volumetric change
ASJC Scopus subject areas
- Otorhinolaryngology