Volume indexes of total, free, and complexed prostate-specific antigen enhance prediction of extraprostatic disease extension in men with nonpalpable prostate cancer

Yoshio Naya, Herbert A. Fritsche, Carol D. Cheli, Thomas A. Stamey, Georg Bartsch, Michael K. Brawer, Stacy Childs, Samir S. Taneja, Herbert Lepor, Alan Wayne Partin, Lori J Sokoll, Daniel Wan-Yui Chan, Richard J. Babaian

Research output: Contribution to journalArticle

Abstract

Objectives. To analyze the ability of volume-adjusted total, complexed, and free prostate-specific antigen (PSA) to predict organ-confined cancer at radical prostatectomy in patients with nonpalpable disease. Methods. Collected sera were assayed for total PSA (tPSA), complexed PSA (cPSA), and free PSA (fPSA) in 78 men who underwent radical prostatectomy with nonpalpable prostate cancer. The pathologic results (organ-confined versus extraprostatic extension [EPE]), tPSA, cPSA, fPSA/tPSA ratio, cPSA/tPSA ratio, fPSA/cPSA ratio, tPSA density (tPSAD), cPSA density (cPSAD), and fPSA density (fPSAD) were compared by the Mann-Whitney U test and receiver operating characteristic curves. Results. Fifteen men (19.2%) had pathologic EPE. After stratifying the patients on the basis of the Beckman tPSA, the cPSAD, tPSAD, and fPSAD were significant predictors of EPE when comparing their respective medians in individuals with tPSA greater than 4.0 ng/mL. Statistically significant differences were noted between patients with and without EPE for tPSAD (P = 0.0015), cPSAD (P = 0.0018), and fPSAD (P = 0.0022), but not for the fPSA/tPSA, cPSA/tPSA, and fPSA/cPSA ratios. The area under the receiver operating characteristic curve was similar for tPSA (0.539) and cPSA (0.542), as it was for tPSAD (0.708), cPSAD (0.700), and fPSAD (0.731). The specificity and diagnostic accuracy of tPSAD, cPSAD, and fPSAD were significantly greater than those of tPSA and cPSA (specificity P

Original languageEnglish (US)
Pages (from-to)1058-1062
Number of pages5
JournalUrology
Volume62
Issue number6
DOIs
StatePublished - Dec 2003
Externally publishedYes

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Prostate-Specific Antigen
Prostatic Neoplasms
Prostatectomy
ROC Curve
Nonparametric Statistics
Serum
Neoplasms

ASJC Scopus subject areas

  • Urology

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Volume indexes of total, free, and complexed prostate-specific antigen enhance prediction of extraprostatic disease extension in men with nonpalpable prostate cancer. / Naya, Yoshio; Fritsche, Herbert A.; Cheli, Carol D.; Stamey, Thomas A.; Bartsch, Georg; Brawer, Michael K.; Childs, Stacy; Taneja, Samir S.; Lepor, Herbert; Partin, Alan Wayne; Sokoll, Lori J; Chan, Daniel Wan-Yui; Babaian, Richard J.

In: Urology, Vol. 62, No. 6, 12.2003, p. 1058-1062.

Research output: Contribution to journalArticle

Naya, Yoshio ; Fritsche, Herbert A. ; Cheli, Carol D. ; Stamey, Thomas A. ; Bartsch, Georg ; Brawer, Michael K. ; Childs, Stacy ; Taneja, Samir S. ; Lepor, Herbert ; Partin, Alan Wayne ; Sokoll, Lori J ; Chan, Daniel Wan-Yui ; Babaian, Richard J. / Volume indexes of total, free, and complexed prostate-specific antigen enhance prediction of extraprostatic disease extension in men with nonpalpable prostate cancer. In: Urology. 2003 ; Vol. 62, No. 6. pp. 1058-1062.
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abstract = "Objectives. To analyze the ability of volume-adjusted total, complexed, and free prostate-specific antigen (PSA) to predict organ-confined cancer at radical prostatectomy in patients with nonpalpable disease. Methods. Collected sera were assayed for total PSA (tPSA), complexed PSA (cPSA), and free PSA (fPSA) in 78 men who underwent radical prostatectomy with nonpalpable prostate cancer. The pathologic results (organ-confined versus extraprostatic extension [EPE]), tPSA, cPSA, fPSA/tPSA ratio, cPSA/tPSA ratio, fPSA/cPSA ratio, tPSA density (tPSAD), cPSA density (cPSAD), and fPSA density (fPSAD) were compared by the Mann-Whitney U test and receiver operating characteristic curves. Results. Fifteen men (19.2{\%}) had pathologic EPE. After stratifying the patients on the basis of the Beckman tPSA, the cPSAD, tPSAD, and fPSAD were significant predictors of EPE when comparing their respective medians in individuals with tPSA greater than 4.0 ng/mL. Statistically significant differences were noted between patients with and without EPE for tPSAD (P = 0.0015), cPSAD (P = 0.0018), and fPSAD (P = 0.0022), but not for the fPSA/tPSA, cPSA/tPSA, and fPSA/cPSA ratios. The area under the receiver operating characteristic curve was similar for tPSA (0.539) and cPSA (0.542), as it was for tPSAD (0.708), cPSAD (0.700), and fPSAD (0.731). The specificity and diagnostic accuracy of tPSAD, cPSAD, and fPSAD were significantly greater than those of tPSA and cPSA (specificity P",
author = "Yoshio Naya and Fritsche, {Herbert A.} and Cheli, {Carol D.} and Stamey, {Thomas A.} and Georg Bartsch and Brawer, {Michael K.} and Stacy Childs and Taneja, {Samir S.} and Herbert Lepor and Partin, {Alan Wayne} and Sokoll, {Lori J} and Chan, {Daniel Wan-Yui} and Babaian, {Richard J.}",
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T1 - Volume indexes of total, free, and complexed prostate-specific antigen enhance prediction of extraprostatic disease extension in men with nonpalpable prostate cancer

AU - Naya, Yoshio

AU - Fritsche, Herbert A.

AU - Cheli, Carol D.

AU - Stamey, Thomas A.

AU - Bartsch, Georg

AU - Brawer, Michael K.

AU - Childs, Stacy

AU - Taneja, Samir S.

AU - Lepor, Herbert

AU - Partin, Alan Wayne

AU - Sokoll, Lori J

AU - Chan, Daniel Wan-Yui

AU - Babaian, Richard J.

PY - 2003/12

Y1 - 2003/12

N2 - Objectives. To analyze the ability of volume-adjusted total, complexed, and free prostate-specific antigen (PSA) to predict organ-confined cancer at radical prostatectomy in patients with nonpalpable disease. Methods. Collected sera were assayed for total PSA (tPSA), complexed PSA (cPSA), and free PSA (fPSA) in 78 men who underwent radical prostatectomy with nonpalpable prostate cancer. The pathologic results (organ-confined versus extraprostatic extension [EPE]), tPSA, cPSA, fPSA/tPSA ratio, cPSA/tPSA ratio, fPSA/cPSA ratio, tPSA density (tPSAD), cPSA density (cPSAD), and fPSA density (fPSAD) were compared by the Mann-Whitney U test and receiver operating characteristic curves. Results. Fifteen men (19.2%) had pathologic EPE. After stratifying the patients on the basis of the Beckman tPSA, the cPSAD, tPSAD, and fPSAD were significant predictors of EPE when comparing their respective medians in individuals with tPSA greater than 4.0 ng/mL. Statistically significant differences were noted between patients with and without EPE for tPSAD (P = 0.0015), cPSAD (P = 0.0018), and fPSAD (P = 0.0022), but not for the fPSA/tPSA, cPSA/tPSA, and fPSA/cPSA ratios. The area under the receiver operating characteristic curve was similar for tPSA (0.539) and cPSA (0.542), as it was for tPSAD (0.708), cPSAD (0.700), and fPSAD (0.731). The specificity and diagnostic accuracy of tPSAD, cPSAD, and fPSAD were significantly greater than those of tPSA and cPSA (specificity P

AB - Objectives. To analyze the ability of volume-adjusted total, complexed, and free prostate-specific antigen (PSA) to predict organ-confined cancer at radical prostatectomy in patients with nonpalpable disease. Methods. Collected sera were assayed for total PSA (tPSA), complexed PSA (cPSA), and free PSA (fPSA) in 78 men who underwent radical prostatectomy with nonpalpable prostate cancer. The pathologic results (organ-confined versus extraprostatic extension [EPE]), tPSA, cPSA, fPSA/tPSA ratio, cPSA/tPSA ratio, fPSA/cPSA ratio, tPSA density (tPSAD), cPSA density (cPSAD), and fPSA density (fPSAD) were compared by the Mann-Whitney U test and receiver operating characteristic curves. Results. Fifteen men (19.2%) had pathologic EPE. After stratifying the patients on the basis of the Beckman tPSA, the cPSAD, tPSAD, and fPSAD were significant predictors of EPE when comparing their respective medians in individuals with tPSA greater than 4.0 ng/mL. Statistically significant differences were noted between patients with and without EPE for tPSAD (P = 0.0015), cPSAD (P = 0.0018), and fPSAD (P = 0.0022), but not for the fPSA/tPSA, cPSA/tPSA, and fPSA/cPSA ratios. The area under the receiver operating characteristic curve was similar for tPSA (0.539) and cPSA (0.542), as it was for tPSAD (0.708), cPSAD (0.700), and fPSAD (0.731). The specificity and diagnostic accuracy of tPSAD, cPSAD, and fPSAD were significantly greater than those of tPSA and cPSA (specificity P

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