Voltage-gated sodium channels assemble and gate as dimers

Jérôme Clatot; Malcolm Hoshi; Xiaoping Wan; Haiyan Liu; Ankur Jain; Krekwit Shinlapawittayatorn; Céline Marionneau; Eckhard Ficker; Taekjip Ha; Isabelle Deschênes

doi:10.1038/s41467-017-02262-0

Voltage-gated sodium channels assemble and gate as dimers

Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes

Research output: Contribution to journal › Article

Abstract

Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.

Original language	English (US)
Article number	2077
Journal	Nature communications
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41467-017-02262-0
State	Published - Dec 1 2017
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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Clatot, J., Hoshi, M., Wan, X., Liu, H., Jain, A., Shinlapawittayatorn, K., Marionneau, C., Ficker, E., Ha, T., & Deschênes, I. (2017). Voltage-gated sodium channels assemble and gate as dimers. Nature communications, 8(1), [2077]. https://doi.org/10.1038/s41467-017-02262-0

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AU - Marionneau, Céline

AU - Ficker, Eckhard

AU - Ha, Taekjip

AU - Deschênes, Isabelle

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