Abstract
Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.
Original language | English (US) |
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Article number | 2077 |
Journal | Nature communications |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1 2017 |
Externally published | Yes |
ASJC Scopus subject areas
- General Chemistry
- General Biochemistry, Genetics and Molecular Biology
- General Physics and Astronomy