VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis

P. A. Muraro; T. Leist; B. Bielekova; H. F. McFarland

doi:10.1016/S0165-5728(00)00362-3

VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis

P. A. Muraro, T. Leist, B. Bielekova, H. F. McFarland

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Effects on adhesion molecules of immune cells might contribute to the mode of action of interferon-β (IFN-β) in multiple sclerosis (MS). We have serially monitored the cell surface expression of integrins CD49d (VLA-4) and CD11a (LFA-1) on fresh T lymphocyte subpopulations from 5 MS patients monthly for 2 months prior to treatment and for 3 months on treatment with IFN-β1b. In parallel, we assessed inflammatory disease activity by monthly contrast-enhanced magnetic resonance imaging (MRI). IFN-β treatment specifically downregulated CD49d expression on CD8+ and CD4+/CD45RO+ 'memory' T lymphocytes and differentially modulated the proportion of CD4+, CD8+ and CD27+ T cells. These effects may play an important role in the reduction of central nervous system cell trafficking and inflammation in MS. Copyright (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	186-194
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	111
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(00)00362-3
State	Published - Nov 1 2000
Externally published	Yes

Keywords

Adhesion molecules
Interferon-β
Multiple sclerosis
T lymphocytes
VLA-4

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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10.1016/S0165-5728(00)00362-3

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title = "VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis",

abstract = "Effects on adhesion molecules of immune cells might contribute to the mode of action of interferon-β (IFN-β) in multiple sclerosis (MS). We have serially monitored the cell surface expression of integrins CD49d (VLA-4) and CD11a (LFA-1) on fresh T lymphocyte subpopulations from 5 MS patients monthly for 2 months prior to treatment and for 3 months on treatment with IFN-β1b. In parallel, we assessed inflammatory disease activity by monthly contrast-enhanced magnetic resonance imaging (MRI). IFN-β treatment specifically downregulated CD49d expression on CD8+ and CD4+/CD45RO+ 'memory' T lymphocytes and differentially modulated the proportion of CD4+, CD8+ and CD27+ T cells. These effects may play an important role in the reduction of central nervous system cell trafficking and inflammation in MS. Copyright (C) 2000 Elsevier Science B.V.",

keywords = "Adhesion molecules, Interferon-β, Multiple sclerosis, T lymphocytes, VLA-4",

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T1 - VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis

AU - Muraro, P. A.

AU - Leist, T.

AU - Bielekova, B.

AU - McFarland, H. F.

PY - 2000/11/1

Y1 - 2000/11/1

N2 - Effects on adhesion molecules of immune cells might contribute to the mode of action of interferon-β (IFN-β) in multiple sclerosis (MS). We have serially monitored the cell surface expression of integrins CD49d (VLA-4) and CD11a (LFA-1) on fresh T lymphocyte subpopulations from 5 MS patients monthly for 2 months prior to treatment and for 3 months on treatment with IFN-β1b. In parallel, we assessed inflammatory disease activity by monthly contrast-enhanced magnetic resonance imaging (MRI). IFN-β treatment specifically downregulated CD49d expression on CD8+ and CD4+/CD45RO+ 'memory' T lymphocytes and differentially modulated the proportion of CD4+, CD8+ and CD27+ T cells. These effects may play an important role in the reduction of central nervous system cell trafficking and inflammation in MS. Copyright (C) 2000 Elsevier Science B.V.

AB - Effects on adhesion molecules of immune cells might contribute to the mode of action of interferon-β (IFN-β) in multiple sclerosis (MS). We have serially monitored the cell surface expression of integrins CD49d (VLA-4) and CD11a (LFA-1) on fresh T lymphocyte subpopulations from 5 MS patients monthly for 2 months prior to treatment and for 3 months on treatment with IFN-β1b. In parallel, we assessed inflammatory disease activity by monthly contrast-enhanced magnetic resonance imaging (MRI). IFN-β treatment specifically downregulated CD49d expression on CD8+ and CD4+/CD45RO+ 'memory' T lymphocytes and differentially modulated the proportion of CD4+, CD8+ and CD27+ T cells. These effects may play an important role in the reduction of central nervous system cell trafficking and inflammation in MS. Copyright (C) 2000 Elsevier Science B.V.

KW - Adhesion molecules

KW - Interferon-β

KW - Multiple sclerosis

KW - T lymphocytes

KW - VLA-4

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VLA-4/CD49d downregulated on primed T lymphocytes during interferon-β therapy in multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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