Vitrectomy, Fluid—Gas Exchange and Transforming Growth Factor—Beta-2 for the Treatment of Traumatic Macular Holes

Jeffrey S. Rubin; Bert M. Glaser; John T. Thompson; Raymond N. Sjaarda; Stephen S. Pappas; Robert P. Murphy

doi:10.1016/S0161-6420(95)30786-5

Vitrectomy, Fluid—Gas Exchange and Transforming Growth Factor—Beta-2 for the Treatment of Traumatic Macular Holes

Jeffrey S. Rubin, Bert M. Glaser, John T. Thompson, Raymond N. Sjaarda, Stephen S. Pappas, Robert P. Murphy

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Purpose: To evaluate whether vitreous surgery is successful in closing full-thickness traumatic macular holes and whether there is subsequent improvement in visual acuity. Methods: Twelve eyes from 12 consecutive patients with traumatic macular holes underwent vitrectomy, fluid-gas exchange and instillation of bovine or recombinant transforming growth factor (TGF)-beta-2. Three of four eyes underwent repeat vitrectomy with TGF-beta-2 after the initial procedure failed to close the macular hole. Results: Eleven (92%) of 12 eyes had closure of the macular hole. Follow-up ranged from 3 to 33 months. Visual acuity improved by 2 or more lines in 8 (67%) of 12 eyes. Six (50%) of 12 eyes improved to 20/40 or better. All 3 eyes that underwent reoperation had successful closure of the macular hole and achieved 2 or more lines of visual improvement. Conclusion: Treatment of full-thickness traumatic macular holes with vitrectomy, fluid-gas exchange, and TGF-beta-2 may result in successful anatomic closure and visual improvement.

Original language	English (US)
Pages (from-to)	1840-1845
Number of pages	6
Journal	Ophthalmology
Volume	102
Issue number	12
DOIs	https://doi.org/10.1016/S0161-6420(95)30786-5
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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title = "Vitrectomy, Fluid—Gas Exchange and Transforming Growth Factor—Beta-2 for the Treatment of Traumatic Macular Holes",

abstract = "Purpose: To evaluate whether vitreous surgery is successful in closing full-thickness traumatic macular holes and whether there is subsequent improvement in visual acuity. Methods: Twelve eyes from 12 consecutive patients with traumatic macular holes underwent vitrectomy, fluid-gas exchange and instillation of bovine or recombinant transforming growth factor (TGF)-beta-2. Three of four eyes underwent repeat vitrectomy with TGF-beta-2 after the initial procedure failed to close the macular hole. Results: Eleven (92%) of 12 eyes had closure of the macular hole. Follow-up ranged from 3 to 33 months. Visual acuity improved by 2 or more lines in 8 (67%) of 12 eyes. Six (50%) of 12 eyes improved to 20/40 or better. All 3 eyes that underwent reoperation had successful closure of the macular hole and achieved 2 or more lines of visual improvement. Conclusion: Treatment of full-thickness traumatic macular holes with vitrectomy, fluid-gas exchange, and TGF-beta-2 may result in successful anatomic closure and visual improvement.",

author = "Rubin, {Jeffrey S.} and Glaser, {Bert M.} and Thompson, {John T.} and Sjaarda, {Raymond N.} and Pappas, {Stephen S.} and Murphy, {Robert P.}",

year = "1995",

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T1 - Vitrectomy, Fluid—Gas Exchange and Transforming Growth Factor—Beta-2 for the Treatment of Traumatic Macular Holes

AU - Rubin, Jeffrey S.

AU - Glaser, Bert M.

AU - Thompson, John T.

AU - Sjaarda, Raymond N.

AU - Pappas, Stephen S.

AU - Murphy, Robert P.

PY - 1995

Y1 - 1995

N2 - Purpose: To evaluate whether vitreous surgery is successful in closing full-thickness traumatic macular holes and whether there is subsequent improvement in visual acuity. Methods: Twelve eyes from 12 consecutive patients with traumatic macular holes underwent vitrectomy, fluid-gas exchange and instillation of bovine or recombinant transforming growth factor (TGF)-beta-2. Three of four eyes underwent repeat vitrectomy with TGF-beta-2 after the initial procedure failed to close the macular hole. Results: Eleven (92%) of 12 eyes had closure of the macular hole. Follow-up ranged from 3 to 33 months. Visual acuity improved by 2 or more lines in 8 (67%) of 12 eyes. Six (50%) of 12 eyes improved to 20/40 or better. All 3 eyes that underwent reoperation had successful closure of the macular hole and achieved 2 or more lines of visual improvement. Conclusion: Treatment of full-thickness traumatic macular holes with vitrectomy, fluid-gas exchange, and TGF-beta-2 may result in successful anatomic closure and visual improvement.

AB - Purpose: To evaluate whether vitreous surgery is successful in closing full-thickness traumatic macular holes and whether there is subsequent improvement in visual acuity. Methods: Twelve eyes from 12 consecutive patients with traumatic macular holes underwent vitrectomy, fluid-gas exchange and instillation of bovine or recombinant transforming growth factor (TGF)-beta-2. Three of four eyes underwent repeat vitrectomy with TGF-beta-2 after the initial procedure failed to close the macular hole. Results: Eleven (92%) of 12 eyes had closure of the macular hole. Follow-up ranged from 3 to 33 months. Visual acuity improved by 2 or more lines in 8 (67%) of 12 eyes. Six (50%) of 12 eyes improved to 20/40 or better. All 3 eyes that underwent reoperation had successful closure of the macular hole and achieved 2 or more lines of visual improvement. Conclusion: Treatment of full-thickness traumatic macular holes with vitrectomy, fluid-gas exchange, and TGF-beta-2 may result in successful anatomic closure and visual improvement.

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ER -

Vitrectomy, Fluid—Gas Exchange and Transforming Growth Factor—Beta-2 for the Treatment of Traumatic Macular Holes

Abstract

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