Vitamin E levels, cognitive impairment and dementia in older persons: The InCHIANTI study

Antonio Cherubini; Antonio Martin; Cristina Andres-Lacueva; Angelo Di Iorio; Marco Lamponi; Patrizia Mecocci; Benedetta Bartali; Annamaria Corsi; Umberto Senin; Luigi Ferrucci

doi:10.1016/j.neurobiolaging.2004.09.002

Vitamin E levels, cognitive impairment and dementia in older persons: The InCHIANTI study

Antonio Cherubini, Antonio Martin, Cristina Andres-Lacueva, Angelo Di Iorio, Marco Lamponi, Patrizia Mecocci, Benedetta Bartali, Annamaria Corsi, Umberto Senin, Luigi Ferrucci

Research output: Contribution to journal › Article

Abstract

There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.

Original language	English (US)
Pages (from-to)	987-994
Number of pages	8
Journal	Neurobiology of Aging
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2004.09.002
State	Published - Jul 2005
Externally published	Yes

Keywords

Antioxidant
Cognitive impairment
Dementia
Elderly
Epidemiological study
Vitamin E

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

Access to Document

10.1016/j.neurobiolaging.2004.09.002

Fingerprint Dive into the research topics of 'Vitamin E levels, cognitive impairment and dementia in older persons: The InCHIANTI study'. Together they form a unique fingerprint.

Cite this

Cherubini, A., Martin, A., Andres-Lacueva, C., Di Iorio, A., Lamponi, M., Mecocci, P., Bartali, B., Corsi, A., Senin, U., & Ferrucci, L. (2005). Vitamin E levels, cognitive impairment and dementia in older persons: The InCHIANTI study. Neurobiology of Aging, 26(7), 987-994. https://doi.org/10.1016/j.neurobiolaging.2004.09.002

Vitamin E levels, cognitive impairment and dementia in older persons : The InCHIANTI study. / Cherubini, Antonio; Martin, Antonio; Andres-Lacueva, Cristina; Di Iorio, Angelo; Lamponi, Marco; Mecocci, Patrizia; Bartali, Benedetta; Corsi, Annamaria; Senin, Umberto; Ferrucci, Luigi.

In: Neurobiology of Aging, Vol. 26, No. 7, 07.2005, p. 987-994.

Research output: Contribution to journal › Article

@article{1d298c704fbe4fbebb9e1d1134c2a6cc,

title = "Vitamin E levels, cognitive impairment and dementia in older persons: The InCHIANTI study",

abstract = "There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.",

keywords = "Antioxidant, Cognitive impairment, Dementia, Elderly, Epidemiological study, Vitamin E",

author = "Antonio Cherubini and Antonio Martin and Cristina Andres-Lacueva and {Di Iorio}, Angelo and Marco Lamponi and Patrizia Mecocci and Benedetta Bartali and Annamaria Corsi and Umberto Senin and Luigi Ferrucci",

year = "2005",

month = jul,

doi = "10.1016/j.neurobiolaging.2004.09.002",

language = "English (US)",

volume = "26",

pages = "987--994",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Vitamin E levels, cognitive impairment and dementia in older persons

T2 - The InCHIANTI study

AU - Cherubini, Antonio

AU - Martin, Antonio

AU - Andres-Lacueva, Cristina

AU - Di Iorio, Angelo

AU - Lamponi, Marco

AU - Mecocci, Patrizia

AU - Bartali, Benedetta

AU - Corsi, Annamaria

AU - Senin, Umberto

AU - Ferrucci, Luigi

PY - 2005/7

Y1 - 2005/7

N2 - There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.

AB - There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.

KW - Antioxidant

KW - Cognitive impairment

KW - Dementia

KW - Elderly

KW - Epidemiological study

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=20044368432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20044368432&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2004.09.002

DO - 10.1016/j.neurobiolaging.2004.09.002

M3 - Article

C2 - 15748776

AN - SCOPUS:20044368432

VL - 26

SP - 987

EP - 994

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 7

ER -