TY - JOUR
T1 - Vitamin E levels, cognitive impairment and dementia in older persons
T2 - The InCHIANTI study
AU - Cherubini, Antonio
AU - Martin, Antonio
AU - Andres-Lacueva, Cristina
AU - Di Iorio, Angelo
AU - Lamponi, Marco
AU - Mecocci, Patrizia
AU - Bartali, Benedetta
AU - Corsi, Annamaria
AU - Senin, Umberto
AU - Ferrucci, Luigi
PY - 2005/7
Y1 - 2005/7
N2 - There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.
AB - There is conflicting evidence that antioxidants contribute to maintaining cognitive function in elderly subjects. We investigated whether vitamin E plasma levels are related to the presence of dementia and cognitive impairment in a population-based cohort study conducted in Italy. A total of 1033 participants aged at least 65 years received clinical and neuropsychological examinations, donated blood for vitamin E analysis and had their diets assessed. Participants with plasma vitamin E levels in the bottom tertile had a significantly higher probability of being demented (OR 2.6, 95% CI 1.0-7.1) and also of suffering from cognitive impairment (OR 2.2, 95% CI 1.2-4.2) compared to those in the highest vitamin E tertile after adjustment for age, gender, education, lipid levels, energy intake, vitamin E intake, and smoking. This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects.
KW - Antioxidant
KW - Cognitive impairment
KW - Dementia
KW - Elderly
KW - Epidemiological study
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=20044368432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20044368432&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2004.09.002
DO - 10.1016/j.neurobiolaging.2004.09.002
M3 - Article
C2 - 15748776
AN - SCOPUS:20044368432
VL - 26
SP - 987
EP - 994
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 7
ER -