Vitamin E deficiency and enhanced platelet function: Reversal following E supplementation

A. M. Lake, M. J. Stuart, F. A. Oski

Research output: Contribution to journalArticle

Abstract

Marked platelet hyperaggregability to adenosine diphosphate, epinephrine, and collagen was demonstrated in two children with vitamin E deficiency, with complete reversal following E supplementation. No clinical thrombotic tendency was observed during the E-deficient state. The action of vitamin E in the schema of platelet arachidonate peroxidation appears to be at the step of phospholipase A activation, or the conversion of arachidonic acid into the cyclic endoperoxides, since the peroxidation product malonaldehyde was increased during the E-deficient state with normalization following E sufficiency.

Original languageEnglish (US)
Pages (from-to)722-725
Number of pages4
JournalThe Journal of pediatrics
Volume90
Issue number5
DOIs
StatePublished - May 1977

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Vitamin E deficiency and enhanced platelet function: Reversal following E supplementation'. Together they form a unique fingerprint.

  • Cite this