TY - JOUR
T1 - Vitamin E deficiency and enhanced platelet function
T2 - Reversal following E supplementation
AU - Lake, A. M.
AU - Stuart, M. J.
AU - Oski, F. A.
PY - 1977/5
Y1 - 1977/5
N2 - Marked platelet hyperaggregability to adenosine diphosphate, epinephrine, and collagen was demonstrated in two children with vitamin E deficiency, with complete reversal following E supplementation. No clinical thrombotic tendency was observed during the E-deficient state. The action of vitamin E in the schema of platelet arachidonate peroxidation appears to be at the step of phospholipase A activation, or the conversion of arachidonic acid into the cyclic endoperoxides, since the peroxidation product malonaldehyde was increased during the E-deficient state with normalization following E sufficiency.
AB - Marked platelet hyperaggregability to adenosine diphosphate, epinephrine, and collagen was demonstrated in two children with vitamin E deficiency, with complete reversal following E supplementation. No clinical thrombotic tendency was observed during the E-deficient state. The action of vitamin E in the schema of platelet arachidonate peroxidation appears to be at the step of phospholipase A activation, or the conversion of arachidonic acid into the cyclic endoperoxides, since the peroxidation product malonaldehyde was increased during the E-deficient state with normalization following E sufficiency.
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U2 - 10.1016/S0022-3476(77)81235-3
DO - 10.1016/S0022-3476(77)81235-3
M3 - Article
C2 - 853335
AN - SCOPUS:0017575116
SN - 0022-3476
VL - 90
SP - 722
EP - 725
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 5
ER -