Vitamin E and Porphyrin Metabolism in Man

Padmanabhan P. Nair, Esteban Mezey, Hari S. Murty, Jeffrey Quartner, Albert I. Mendeloff

Research output: Contribution to journalArticlepeer-review

Abstract

Four patients with symptoms of porphyria were treated with water soluble vitamin E. In all four patients, urinary excretion of -aminolevulinicacid, porphobilinogen, coproporphyrins, and uroporphyrins, which were initially elevated, decreased to normal levels following therapy. The initial vitamin E levels in whole blood which were lower than normal responded to treatment with the vitamin and paralleled clinical improvement. The effects of vitamin E on porphyrin metabolism were examined in a group of six male chronic alcoholic patients without clinical evidence of chronic liver disease. The coproporphyrinuria associated with alcoholism was found to be nonresponsive to vitamin E. Our observations indicate that the action of vitamin E in porphyria is probably not mediated through a reversal of the effects of any concurrent alcoholism.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalArchives of internal medicine
Volume128
Issue number3
DOIs
StatePublished - Sep 1971

ASJC Scopus subject areas

  • Internal Medicine

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