TY - JOUR
T1 - Vitamin E and Porphyrin Metabolism in Man
AU - Nair, Padmanabhan P.
AU - Mezey, Esteban
AU - Murty, Hari S.
AU - Quartner, Jeffrey
AU - Mendeloff, Albert I.
PY - 1971/9
Y1 - 1971/9
N2 - Four patients with symptoms of porphyria were treated with water soluble vitamin E. In all four patients, urinary excretion of -aminolevulinicacid, porphobilinogen, coproporphyrins, and uroporphyrins, which were initially elevated, decreased to normal levels following therapy. The initial vitamin E levels in whole blood which were lower than normal responded to treatment with the vitamin and paralleled clinical improvement. The effects of vitamin E on porphyrin metabolism were examined in a group of six male chronic alcoholic patients without clinical evidence of chronic liver disease. The coproporphyrinuria associated with alcoholism was found to be nonresponsive to vitamin E. Our observations indicate that the action of vitamin E in porphyria is probably not mediated through a reversal of the effects of any concurrent alcoholism.
AB - Four patients with symptoms of porphyria were treated with water soluble vitamin E. In all four patients, urinary excretion of -aminolevulinicacid, porphobilinogen, coproporphyrins, and uroporphyrins, which were initially elevated, decreased to normal levels following therapy. The initial vitamin E levels in whole blood which were lower than normal responded to treatment with the vitamin and paralleled clinical improvement. The effects of vitamin E on porphyrin metabolism were examined in a group of six male chronic alcoholic patients without clinical evidence of chronic liver disease. The coproporphyrinuria associated with alcoholism was found to be nonresponsive to vitamin E. Our observations indicate that the action of vitamin E in porphyria is probably not mediated through a reversal of the effects of any concurrent alcoholism.
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U2 - 10.1001/archinte.1971.00310210087008
DO - 10.1001/archinte.1971.00310210087008
M3 - Article
C2 - 5093212
AN - SCOPUS:0015122375
SN - 0003-9926
VL - 128
SP - 411
EP - 415
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 3
ER -