Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys

Jane F. Reckelhoff, Vijaya Kanji, Lorraine C Racusen, Ann Marie Schmidt, Shu Du Yan, Jason Morrow, L. Jackson Roberts, Abdulla K. Salahudeen

Research output: Contribution to journalArticle

Abstract

Aging results in progressive glomerular sclerosis and reductions in glomerular filtration rate (GFR). Oxidative stress may be an important mechanism for the aging process, but to date the role of oxidative stress on renal aging has not been determined. The present study was performed to determine whether age-related alterations in renal hemodynamics and morphology were associated with oxidative stress and whether this could be attenuated by chronic administration of vitamin E. Rats, aged 13 mo, were given either control diet containing vitamin E 50 IU/kg (n = 6) or a high- vitamin E diet (5,000 IU/kg; n = 6) for 9 mo. Another group of rats (3-4 mo old; n = 7) served as young controls. Aging was accompanied by a 60% reduction in GFR, a threefold increase in renal F2 isoprostanes, newly discovered vasoconstrictive F2-like prostaglandins generated by free radical-mediated lipid peroxidation. Renal aging was also associated with an increase in oxidant-sensitive heme oxygenase, advanced glycosylation end products (AGEs), and the AGE receptor, RAGE, AGE-RAGE interaction has been shown to induce oxidative stress. With high-vitamin E diet, GFR was increased by 50%, F2 isoprostanes were suppressed, and expression of heme oxygenase and RAGE was attenuated. There was also a tendency for glomerular sclerosis to be attenuated. These data demonstrate that age-related decline in renal function is accompanied by oxidative stress and that administration of antioxidants, such as vitamin E, could attenuate the decline in renal function.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume274
Issue number3 43-3
StatePublished - Mar 1998

Fingerprint

F2-Isoprostanes
Vitamin E
Lipid Peroxidation
Oxidative Stress
Kidney
Glomerular Filtration Rate
Heme Oxygenase (Decyclizing)
Sclerosis
Diet
Advanced Glycosylation End Products
Dinoprost
Oxidants
Free Radicals
Antioxidants
Hemodynamics

Keywords

  • Advanced glycosylation end products
  • Free radicals
  • Glomerular filtration rate
  • Heme oxygenase

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Reckelhoff, J. F., Kanji, V., Racusen, L. C., Schmidt, A. M., Yan, S. D., Morrow, J., ... Salahudeen, A. K. (1998). Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 274(3 43-3).

Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. / Reckelhoff, Jane F.; Kanji, Vijaya; Racusen, Lorraine C; Schmidt, Ann Marie; Yan, Shu Du; Morrow, Jason; Roberts, L. Jackson; Salahudeen, Abdulla K.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 274, No. 3 43-3, 03.1998.

Research output: Contribution to journalArticle

Reckelhoff, JF, Kanji, V, Racusen, LC, Schmidt, AM, Yan, SD, Morrow, J, Roberts, LJ & Salahudeen, AK 1998, 'Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 274, no. 3 43-3.
Reckelhoff, Jane F. ; Kanji, Vijaya ; Racusen, Lorraine C ; Schmidt, Ann Marie ; Yan, Shu Du ; Morrow, Jason ; Roberts, L. Jackson ; Salahudeen, Abdulla K. / Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1998 ; Vol. 274, No. 3 43-3.
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abstract = "Aging results in progressive glomerular sclerosis and reductions in glomerular filtration rate (GFR). Oxidative stress may be an important mechanism for the aging process, but to date the role of oxidative stress on renal aging has not been determined. The present study was performed to determine whether age-related alterations in renal hemodynamics and morphology were associated with oxidative stress and whether this could be attenuated by chronic administration of vitamin E. Rats, aged 13 mo, were given either control diet containing vitamin E 50 IU/kg (n = 6) or a high- vitamin E diet (5,000 IU/kg; n = 6) for 9 mo. Another group of rats (3-4 mo old; n = 7) served as young controls. Aging was accompanied by a 60{\%} reduction in GFR, a threefold increase in renal F2 isoprostanes, newly discovered vasoconstrictive F2-like prostaglandins generated by free radical-mediated lipid peroxidation. Renal aging was also associated with an increase in oxidant-sensitive heme oxygenase, advanced glycosylation end products (AGEs), and the AGE receptor, RAGE, AGE-RAGE interaction has been shown to induce oxidative stress. With high-vitamin E diet, GFR was increased by 50{\%}, F2 isoprostanes were suppressed, and expression of heme oxygenase and RAGE was attenuated. There was also a tendency for glomerular sclerosis to be attenuated. These data demonstrate that age-related decline in renal function is accompanied by oxidative stress and that administration of antioxidants, such as vitamin E, could attenuate the decline in renal function.",
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