Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders

Elif M. Sikoglu, Ana A.Liso Navarro, Debra Starr, Yael Dvir, Benjamin Udoka Nwosu, Suzanne M. Czerniak, Ryan C. Rogan, Martha C. Castro, Richard A.E. Edden, Jean A. Frazier, Constance M. Moore

Research output: Contribution to journalArticle

Abstract

Objective: We aimed to determine the effect of an open-label 8 week Vitamin D3 supplementation on manic symptoms, anterior cingulate cortex (ACC) glutamate, and γ-aminobutyric acid (GABA) in youth exhibiting symptoms of mania; that is, patients with bipolar spectrum disorders (BSD). We hypothesized that an 8 week Vitamin D3 supplementation would improve symptoms of mania, decrease ACC glutamate, and increase ACC GABA in BSD patients. Single time point metabolite levels were also evaluated in typically developing children (TD). Methods: The BSD group included patients not only diagnosed with BD but also those exhibiting bipolar symptomology, including BD not otherwise specified (BD-NOS) and subthreshold mood ratings (Young Mania Rating Scale [YMRS] ≥8 and Clinical Global Impressions - Severity [CGI-S] ≥3). Inclusion criteria were: male or female participants, 6-17 years old. Sixteen youth with BSD exhibiting manic symptoms and 19 TD were included. BSD patients were asked to a take daily dose (2000 IU) of Vitamin D3 (for 8 weeks) as a supplement. Neuroimaging data were acquired in both groups at baseline, and also for the BSD group at the end of 8 week Vitamin D3 supplementation. Results: Baseline ACC GABA/creatine (Cr) was lower in BSD than in TD (F[1,31]=8.91, p=0.007). Following an 8 week Vitamin D3 supplementation, in BSD patients, there was a significant decrease in YMRS scores (t=-3.66, p=0.002, df=15) and Children's Depression Rating Scale (CDRS) scores (t=-2.93, p=0.01, df=15); and a significant increase in ACC GABA (t=3.18, p=0.007, df=14). Conclusions: Following an 8 week open label trial with Vitamin D3, BSD patients exhibited improvement in their mood symptoms in conjunction with their brain neurochemistry.

Original languageEnglish (US)
Pages (from-to)415-424
Number of pages10
JournalJournal of child and adolescent psychopharmacology
Volume25
Issue number5
DOIs
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Vitamin D<sub>3</sub> Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders'. Together they form a unique fingerprint.

  • Cite this

    Sikoglu, E. M., Navarro, A. A. L., Starr, D., Dvir, Y., Nwosu, B. U., Czerniak, S. M., Rogan, R. C., Castro, M. C., Edden, R. A. E., Frazier, J. A., & Moore, C. M. (2015). Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders. Journal of child and adolescent psychopharmacology, 25(5), 415-424. https://doi.org/10.1089/cap.2014.0110