Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis

Ellen Mahar Mowry, Judith A. James, Lauren B. Krupp, Emmanuelle Waubant

Research output: Contribution to journalArticle

Abstract

Background: The relative contribution and interaction of risk factors for multiple sclerosis (MS) have not been evaluated.Objectives: To determine whether vitamin D status is associated with antibody levels to common viruses in pediatric-onset MS or clinically isolated syndrome (CIS) patients and controls.Methods: We assessed whether vitamin D status was associated with viral antibody levels to Epstein-Barr virus, cytomegalovirus (CMV), and herpes simplex virus (HSV)-1 or -2 in subjects who demonstrated evidence of remote infection with these viruses and whether these associations differed depending on disease status.Results: In 140 subjects, vitamin D status was weakly associated with antibody levels to CMV but not to the other viruses. However, there were some interactions between vitamin D status and disease state. Among those with vitamin D sufficiency (≥30 ng/ml), MS/CIS patients had higher antibody levels to Epstein-Barr nuclear antigen-1 than controls. Vitamin D sufficiency was associated with higher CMV antibody levels in MS/CIS subjects but lower CMV antibody levels in controls. Higher vitamin D levels appeared to be associated with higher titers to HSV-2 in MS/CIS patients but not controls.Conclusions: Vitamin D status may be differentially associated with antibody levels to common childhood viruses among seropositive subjects.

Original languageEnglish (US)
Pages (from-to)666-671
Number of pages6
JournalMultiple Sclerosis
Volume17
Issue number6
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Vitamin D
Multiple Sclerosis
Pediatrics
Viruses
Antibodies
Cytomegalovirus
Viral Antibodies
Nuclear Antigens
Human Herpesvirus 2
Human Herpesvirus 1
Virus Diseases
Human Herpesvirus 4

Keywords

  • cytomegalovirus
  • Epstein-Barr virus infections
  • herpes simplex
  • multiple sclerosis
  • risk factors
  • vitamin D

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis. / Mowry, Ellen Mahar; James, Judith A.; Krupp, Lauren B.; Waubant, Emmanuelle.

In: Multiple Sclerosis, Vol. 17, No. 6, 2011, p. 666-671.

Research output: Contribution to journalArticle

Mowry, Ellen Mahar ; James, Judith A. ; Krupp, Lauren B. ; Waubant, Emmanuelle. / Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis. In: Multiple Sclerosis. 2011 ; Vol. 17, No. 6. pp. 666-671.
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