Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk

Jiyoung Ahn, Demetrius Albanes, Sonja I. Berndt, Ulrike Peters, Nilanjan Chatterjee, Neal D. Freedman, Christian C. Abnet, Wen Yi Huang, Adam S. Kibel, David E. Crawford, Stephanie J. Weinstein, Stephen J. Chanock, Arthur Schatzkin, Richard B. Hayes

Research output: Contribution to journalArticle

Abstract

We systematically investigated the association of 48 SNPS in four vitamin D metabolizing genes [CYP27AI, GC, CYP27B1 and CYP24A1] with serum 25-hydroxyvitamin D [25(OH)D] and 1, 25-dihydroxyvitamin D [1,25(OH)2D] levels and the association of these SNPS and an additional 164 SNPS in eight downstream mediators of vitamin D signaling [VDR, RXRA, RXRB, PPAR, NCOA1, NCOA2, NCOA3 and SMAD3] with prostate cancer risk in the 749 incident prostate cancer cases and 781 controls of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. 25(OH)D (all cases and controls) and 1,25(OH)2D (a subset of 150 controls) levels were measured by radioimmunoassay and SNP data were genotyped as part of a genome-wide scan. Among investigated SNPS, only four tag SNPS in GC, the major serum 25(OH)D carrier, were associated with 25(OH)D levels; no SNPS were associated with 1,25(OH)2D levels. None of the 212 SNPS examined were associated with cancer risk overall. Among men in the lowest tertile of serum 25(OH)D (

Original languageEnglish (US)
Pages (from-to)769-776
Number of pages8
JournalCarcinogenesis
Volume30
Issue number5
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Vitamin D
Prostatic Neoplasms
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Serum
Genes
Peroxisome Proliferator-Activated Receptors
Early Detection of Cancer
Ovarian Neoplasms
Radioimmunoassay
Single Nucleotide Polymorphism
Colorectal Neoplasms
Lung Neoplasms
Genome
Neoplasms
Vitamin D3 24-Hydroxylase
1,25-dihydroxyvitamin D
25-hydroxyvitamin D

ASJC Scopus subject areas

  • Cancer Research

Cite this

Ahn, J., Albanes, D., Berndt, S. I., Peters, U., Chatterjee, N., Freedman, N. D., ... Hayes, R. B. (2009). Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis, 30(5), 769-776. https://doi.org/10.1093/carcin/bgp055

Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. / Ahn, Jiyoung; Albanes, Demetrius; Berndt, Sonja I.; Peters, Ulrike; Chatterjee, Nilanjan; Freedman, Neal D.; Abnet, Christian C.; Huang, Wen Yi; Kibel, Adam S.; Crawford, David E.; Weinstein, Stephanie J.; Chanock, Stephen J.; Schatzkin, Arthur; Hayes, Richard B.

In: Carcinogenesis, Vol. 30, No. 5, 2009, p. 769-776.

Research output: Contribution to journalArticle

Ahn, J, Albanes, D, Berndt, SI, Peters, U, Chatterjee, N, Freedman, ND, Abnet, CC, Huang, WY, Kibel, AS, Crawford, DE, Weinstein, SJ, Chanock, SJ, Schatzkin, A & Hayes, RB 2009, 'Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk', Carcinogenesis, vol. 30, no. 5, pp. 769-776. https://doi.org/10.1093/carcin/bgp055
Ahn, Jiyoung ; Albanes, Demetrius ; Berndt, Sonja I. ; Peters, Ulrike ; Chatterjee, Nilanjan ; Freedman, Neal D. ; Abnet, Christian C. ; Huang, Wen Yi ; Kibel, Adam S. ; Crawford, David E. ; Weinstein, Stephanie J. ; Chanock, Stephen J. ; Schatzkin, Arthur ; Hayes, Richard B. / Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. In: Carcinogenesis. 2009 ; Vol. 30, No. 5. pp. 769-776.
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