Vitamin D receptor polymorphisms and renal cancer risk in Central and Eastern Europe

S. Karami, P. Brennan, R. J. Hung, P. Boffetta, J. Toro, R. T. Wilson, D. Zaridze, M. Navratilova, N. Chatterjee, D. Mates, V. Janout, H. Kollarova, V. Bencko, N. Szeszenia-Dabrowska, I. Holcatova, A. Moukeria, R. Welch, S. Chanock, N. Rothman, W. H. ChowL. E. Moore

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies investigated the role of vitamin D intake and cancer risk. The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk. Three common VDR gene polymorphisms (BsmI, FokI, TaqI) were evaluated among 925 RCC cases and 1192 controls enrolled in a hospital-based case-control study conducted in Central and Eastern Europe. Overall associations with RCC risk were not observed; however, subgroup analyses revealed associations after stratification by median age of diagnosis and family history of cancer. Among subjects over 60 yr, reduced risks were observed among carriers of the f alleles in the FokI single-nuceotide polymorphism (SNP) (odds ratio [OR] = 0.61 for Ff and OR = 0.74 for ff genotypes) compared to subjects with the FF genotype (P trend = 0.04; P interaction = 0.004). Subjects with the BB BsmI genotype and a positive family history of cancer had lower risk compared to subjects with the bb allele (OR = 0.60; 95% CI: 0.33-1.1; P trend = 0.05). Genotype associations with these subgroups were not modified when dietary sources of vitamin D or calcium were considered. Additional studies of genetic variation in the VDR gene are warranted.

Original languageEnglish (US)
Pages (from-to)367-372
Number of pages6
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume71
Issue number6
DOIs
StatePublished - Jan 2008
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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