Vitamin D metabolic pathway genes and pancreatic cancer risk

Hannah Arem, Kai Yu, Xiaoqin Xiong, Kristin Moy, Neal D. Freedman, Susan T. Mayne, Demetrius Albanes, Alan A. Arslan, Melissa Austin, William R. Bamlet, Laura Beane-Freeman, Paige Bracci, Federico Canzian, Michelle Cotterchio, Eric J. Duell, Steve Gallinger, Graham G. Giles, Michael S Goggins, Phyllis J. Goodman, Patricia HartgeManal Hassan, Kathy Helzlsouer, Brian Henderson, Elizabeth A. Holly, Robert Hoover, Eric J. Jacobs, Aruna Kamineni, Alison Klein, Eric Klein, Laurence N. Kolonel, Donghui Li, Núria Malats, Satu Männistö, Marjorie L. McCullough, Sara H. Olson, Irene Orlow, Ulrike Peters, Gloria M. Petersen, Miquel Porta, Gianluca Severi, Xiao Ou Shu, Kala Visvanathan, Emily White, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Geoffrey S. Tobias, Dennis Maeder, Michelle Brotzman, Harvey Risch, Joshua N. Sampson, Rachael Z. Stolzenberg-Solomon

Research output: Contribution to journalArticle

Abstract

Evidence on the association between vitamin D status and pancreatic cancer risk is inconsistent. This inconsistency may be partially attributable to variation in vitamin D regulating genes. We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Our study included 3,583 pancreatic cancer cases and 7,053 controls from the genome-wide association studies of pancreatic cancer PanScans-I-III. We used the Adaptive Joint Test and the Adaptive Rank Truncated Product statistic for pathway and gene analyses, and unconditional logistic regression for SNP analyses, adjusting for age, sex, study and population stratification. We examined effect modification by circulating vitamin D concentration (≤50, >50 nmol/L) for the most significant SNPs using a subset of cohort cases (n = 713) and controls (n = 878). The vitamin D metabolic pathway was not associated with pancreatic cancer risk (p = 0.830). Of the individual genes, none were associated with pancreatic cancer risk at a significance level of p

Original languageEnglish (US)
Article numbere0117574
JournalPLoS One
Volume10
Issue number3
DOIs
StatePublished - Mar 23 2015

Fingerprint

pancreatic neoplasms
vitamin D
Metabolic Networks and Pathways
Pancreatic Neoplasms
Vitamin D
biochemical pathways
Genes
Polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Nucleotides
genes
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Genome-Wide Association Study
adenocarcinoma
Logistics
Adenocarcinoma
statistics
Joints
Logistic Models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Arem, H., Yu, K., Xiong, X., Moy, K., Freedman, N. D., Mayne, S. T., ... Stolzenberg-Solomon, R. Z. (2015). Vitamin D metabolic pathway genes and pancreatic cancer risk. PLoS One, 10(3), [e0117574]. https://doi.org/10.1371/journal.pone.0117574

Vitamin D metabolic pathway genes and pancreatic cancer risk. / Arem, Hannah; Yu, Kai; Xiong, Xiaoqin; Moy, Kristin; Freedman, Neal D.; Mayne, Susan T.; Albanes, Demetrius; Arslan, Alan A.; Austin, Melissa; Bamlet, William R.; Beane-Freeman, Laura; Bracci, Paige; Canzian, Federico; Cotterchio, Michelle; Duell, Eric J.; Gallinger, Steve; Giles, Graham G.; Goggins, Michael S; Goodman, Phyllis J.; Hartge, Patricia; Hassan, Manal; Helzlsouer, Kathy; Henderson, Brian; Holly, Elizabeth A.; Hoover, Robert; Jacobs, Eric J.; Kamineni, Aruna; Klein, Alison; Klein, Eric; Kolonel, Laurence N.; Li, Donghui; Malats, Núria; Männistö, Satu; McCullough, Marjorie L.; Olson, Sara H.; Orlow, Irene; Peters, Ulrike; Petersen, Gloria M.; Porta, Miquel; Severi, Gianluca; Shu, Xiao Ou; Visvanathan, Kala; White, Emily; Yu, Herbert; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Tobias, Geoffrey S.; Maeder, Dennis; Brotzman, Michelle; Risch, Harvey; Sampson, Joshua N.; Stolzenberg-Solomon, Rachael Z.

In: PLoS One, Vol. 10, No. 3, e0117574, 23.03.2015.

Research output: Contribution to journalArticle

Arem, H, Yu, K, Xiong, X, Moy, K, Freedman, ND, Mayne, ST, Albanes, D, Arslan, AA, Austin, M, Bamlet, WR, Beane-Freeman, L, Bracci, P, Canzian, F, Cotterchio, M, Duell, EJ, Gallinger, S, Giles, GG, Goggins, MS, Goodman, PJ, Hartge, P, Hassan, M, Helzlsouer, K, Henderson, B, Holly, EA, Hoover, R, Jacobs, EJ, Kamineni, A, Klein, A, Klein, E, Kolonel, LN, Li, D, Malats, N, Männistö, S, McCullough, ML, Olson, SH, Orlow, I, Peters, U, Petersen, GM, Porta, M, Severi, G, Shu, XO, Visvanathan, K, White, E, Yu, H, Zeleniuch-Jacquotte, A, Zheng, W, Tobias, GS, Maeder, D, Brotzman, M, Risch, H, Sampson, JN & Stolzenberg-Solomon, RZ 2015, 'Vitamin D metabolic pathway genes and pancreatic cancer risk', PLoS One, vol. 10, no. 3, e0117574. https://doi.org/10.1371/journal.pone.0117574
Arem H, Yu K, Xiong X, Moy K, Freedman ND, Mayne ST et al. Vitamin D metabolic pathway genes and pancreatic cancer risk. PLoS One. 2015 Mar 23;10(3). e0117574. https://doi.org/10.1371/journal.pone.0117574
Arem, Hannah ; Yu, Kai ; Xiong, Xiaoqin ; Moy, Kristin ; Freedman, Neal D. ; Mayne, Susan T. ; Albanes, Demetrius ; Arslan, Alan A. ; Austin, Melissa ; Bamlet, William R. ; Beane-Freeman, Laura ; Bracci, Paige ; Canzian, Federico ; Cotterchio, Michelle ; Duell, Eric J. ; Gallinger, Steve ; Giles, Graham G. ; Goggins, Michael S ; Goodman, Phyllis J. ; Hartge, Patricia ; Hassan, Manal ; Helzlsouer, Kathy ; Henderson, Brian ; Holly, Elizabeth A. ; Hoover, Robert ; Jacobs, Eric J. ; Kamineni, Aruna ; Klein, Alison ; Klein, Eric ; Kolonel, Laurence N. ; Li, Donghui ; Malats, Núria ; Männistö, Satu ; McCullough, Marjorie L. ; Olson, Sara H. ; Orlow, Irene ; Peters, Ulrike ; Petersen, Gloria M. ; Porta, Miquel ; Severi, Gianluca ; Shu, Xiao Ou ; Visvanathan, Kala ; White, Emily ; Yu, Herbert ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Tobias, Geoffrey S. ; Maeder, Dennis ; Brotzman, Michelle ; Risch, Harvey ; Sampson, Joshua N. ; Stolzenberg-Solomon, Rachael Z. / Vitamin D metabolic pathway genes and pancreatic cancer risk. In: PLoS One. 2015 ; Vol. 10, No. 3.
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