Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

Deanna Saylor, Gertrude Nakigozi, Carlos A. Pardo, Alice Kisakye, Anupama Kumar, Noeline Nakasujja, Kevin R. Robertson, Ronald H. Gray, Maria J. Wawer, Ned Sacktor

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

Original languageEnglish (US)
Pages (from-to)410-414
Number of pages5
JournalJournal of neurovirology
Volume25
Issue number3
DOIs
StatePublished - Jun 15 2019

Keywords

  • Africa
  • Epidemiology
  • HIV
  • HIV-associated neurocognitive disorder
  • Vitamin D

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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