TY - JOUR
T1 - Vitamin D is associated with cognitive function in elders receiving home health services
AU - Buell, Jennifer S.
AU - Scott, Tammy M.
AU - Dawson-Hughes, Bess
AU - Dallal, Gerard E.
AU - Rosenberg, Irwin H.
AU - Folstein, Marshal F.
AU - Tucker, Katherine L.
N1 - Funding Information:
The authors would like to thank the efforts of John Griffith, PhD, Lori Lyn Price, MS, and the Tufts-NEMC General Clinical Research Facility for their support and guidance in the data management of this study and Dr Wendy Qiu for her dedication to the conduct and oversight of the study procedures. J.E.B. designed the analysis and drafted the manuscript; T.M.S. advised on experimental design and interpretation of the cognitive data; G.E.D. advised on data analysis; B.D.H., I.H.R., and M.F.F. provided advice on the content; and K.L.T. oversaw the data analysis and final preparation of the manuscript. All authors reviewed the final version. This research was supported in part by National Institutes of Health grant, AG21790-01; the Tufts New England Medical Center General Clinical Research Center, funded by the Nat ional Centerfor Research Resources of the NIH; and by United States Department of Agriculture Agricultural Research Service agreement # 58-1950-7-707.
PY - 2009/8
Y1 - 2009/8
N2 - Background. The objective of this study was to examine the association between 25-hydroxyvitamin D, 25(OH)D, and cognitive function. Methods. A cross-sectional investigation of 25(OH)D and cognition was completed in 377 black and 703 non-black (mainly Caucasian) elders (65-99 years) participating in the nutrition and memory in elders study. Participants underwent a comprehensive neuropsychological battery, and 25(OH)D concentrations were obtained. Results. More than 65% of elders had suboptimal 25(OH)D concentrations (≤20 ng/mL or ≤50 nmol/L). Approximately 18% were deficient in 25(OH)D (<10 ng/mL or <25 nmol/L). After adjusting for age, sex, race, body mass index, education, center, kidney function, seasonality, physical activity, and alcohol use, 25(OH)D was associated with better performance on trails A (β=-0.49, p <.03), trails B (β=-0.73, p <.02), digit symbol (β= 0.19, p <.001), matrix reasoning (β= 0.04, p <.02), and block design (β= 0.07, p <.04) tests. Associations remained after adjustment for homocysteine, apoE4 allele, plasma B vitamins, and multivitamin use (y/n). 25(OH)D concentrations >20 ng/mL were associated with better performance on tests of executive function, including trails A (80.5 vs 95, p <.05), trails B (205s vs 226s, p <.05), matrix reasoning (7.8 vs 7.0, p =.03), and digit symbol (31.5 vs 37, p <.01). There were no associations between 25(OH)D and memory tests. Factor analysis yielded factors for memory, executive function, and attention/ processing speed. After adjustment, 25(OH)D was associated with the executive function (β= 0.01, p <0.01) and attention/ processing speed factors (β= 0.01, p =.03), but not the memory factor (β=-0.001, p = 0.65). Conclusions. 25(OH)D was positively associated with cognitive performance, particularly with measures of executive function in this elderly population.
AB - Background. The objective of this study was to examine the association between 25-hydroxyvitamin D, 25(OH)D, and cognitive function. Methods. A cross-sectional investigation of 25(OH)D and cognition was completed in 377 black and 703 non-black (mainly Caucasian) elders (65-99 years) participating in the nutrition and memory in elders study. Participants underwent a comprehensive neuropsychological battery, and 25(OH)D concentrations were obtained. Results. More than 65% of elders had suboptimal 25(OH)D concentrations (≤20 ng/mL or ≤50 nmol/L). Approximately 18% were deficient in 25(OH)D (<10 ng/mL or <25 nmol/L). After adjusting for age, sex, race, body mass index, education, center, kidney function, seasonality, physical activity, and alcohol use, 25(OH)D was associated with better performance on trails A (β=-0.49, p <.03), trails B (β=-0.73, p <.02), digit symbol (β= 0.19, p <.001), matrix reasoning (β= 0.04, p <.02), and block design (β= 0.07, p <.04) tests. Associations remained after adjustment for homocysteine, apoE4 allele, plasma B vitamins, and multivitamin use (y/n). 25(OH)D concentrations >20 ng/mL were associated with better performance on tests of executive function, including trails A (80.5 vs 95, p <.05), trails B (205s vs 226s, p <.05), matrix reasoning (7.8 vs 7.0, p =.03), and digit symbol (31.5 vs 37, p <.01). There were no associations between 25(OH)D and memory tests. Factor analysis yielded factors for memory, executive function, and attention/ processing speed. After adjustment, 25(OH)D was associated with the executive function (β= 0.01, p <0.01) and attention/ processing speed factors (β= 0.01, p =.03), but not the memory factor (β=-0.001, p = 0.65). Conclusions. 25(OH)D was positively associated with cognitive performance, particularly with measures of executive function in this elderly population.
KW - Cognitive function
KW - Dementia
KW - Elderly people
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=67650663282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650663282&partnerID=8YFLogxK
U2 - 10.1093/gerona/glp032
DO - 10.1093/gerona/glp032
M3 - Article
C2 - 19377013
AN - SCOPUS:67650663282
SN - 1079-5006
VL - 64
SP - 888
EP - 895
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 8
ER -