Vitamin D insufficiency among hospitalised children in the Northern Territory

Michael J. Binks, Heidi C. Smith-Vaughan, Naor Bar-Zeev, Anne B. Chang, Ross M. Andrews

Research output: Contribution to journalArticle

Abstract

Aim Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Methods Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. Results There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels <75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Conclusions Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalJournal of Paediatrics and Child Health
Volume50
Issue number7
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Northern Territory
Hospitalized Child
Vitamin D
Respiratory Tract Infections
Gastroenteritis
Hospitalization
Bronchiolitis
Vitamin D Deficiency
Liquid Chromatography
Mass Spectrometry
Pneumonia
Odds Ratio
Confidence Intervals
Pediatrics

Keywords

  • acute lower respiratory infection
  • ALRI
  • Northern Territory
  • vitamin D

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Vitamin D insufficiency among hospitalised children in the Northern Territory. / Binks, Michael J.; Smith-Vaughan, Heidi C.; Bar-Zeev, Naor; Chang, Anne B.; Andrews, Ross M.

In: Journal of Paediatrics and Child Health, Vol. 50, No. 7, 01.01.2014, p. 512-518.

Research output: Contribution to journalArticle

Binks, Michael J. ; Smith-Vaughan, Heidi C. ; Bar-Zeev, Naor ; Chang, Anne B. ; Andrews, Ross M. / Vitamin D insufficiency among hospitalised children in the Northern Territory. In: Journal of Paediatrics and Child Health. 2014 ; Vol. 50, No. 7. pp. 512-518.
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abstract = "Aim Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Methods Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64{\%} male; 57{\%} Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. Results There were 44 (59{\%}) ALRI-classified hospitalisations and 30 (41{\%}) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30{\%}) and pneumonia (n = 21, 28{\%}), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27{\%}). Overall, 24/74 (32{\%}) children had 25OHD3 levels <75 nmol/L (insufficiency). For children hospitalised with ALRI, 23{\%} (10/44) had vitamin D insufficiency compared with 47{\%} (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95{\%} confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60{\%}) children hospitalised for gastroenteritis had vitamin D insufficiency. Conclusions Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).",
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N2 - Aim Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Methods Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. Results There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels <75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Conclusions Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).

AB - Aim Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Methods Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. Results There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels <75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Conclusions Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).

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