TY - JOUR
T1 - Vitamin D
T2 - Evidence for its role as a prognostic factor in multiple sclerosis
AU - Mowry, Ellen M.
N1 - Funding Information:
Dr. Mowry is funded by NIHK23NS067055 , and the pediatric-onset MS study presented herein was funded by the National Multiple Sclerosis Society . These entities did not have any involvement in the design or conduct of the study or of this article.
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Vitamin D insufficiency has been shown to be associated with increased susceptibility to multiple sclerosis (MS), but until recently, it was unclear if vitamin D status also influences the prognosis of the disease. In experimental autoimmune encephalomyelitis, a mouse model of MS, the administration of vitamin D reduces the severity of the disease. Initial reports in MS of inverse associations between vitamin D levels and disability or relapse rate were encouraging, but the cross-sectional or retrospective study designs limited their interpretability. More recently, studies of pediatric-onset and adult MS have demonstrated that among those with established MS, those with lower vitamin D levels are at higher risk for subsequent relapse. These observational data provide strong support for randomized controlled trials of vitamin D supplementation in MS.
AB - Vitamin D insufficiency has been shown to be associated with increased susceptibility to multiple sclerosis (MS), but until recently, it was unclear if vitamin D status also influences the prognosis of the disease. In experimental autoimmune encephalomyelitis, a mouse model of MS, the administration of vitamin D reduces the severity of the disease. Initial reports in MS of inverse associations between vitamin D levels and disability or relapse rate were encouraging, but the cross-sectional or retrospective study designs limited their interpretability. More recently, studies of pediatric-onset and adult MS have demonstrated that among those with established MS, those with lower vitamin D levels are at higher risk for subsequent relapse. These observational data provide strong support for randomized controlled trials of vitamin D supplementation in MS.
KW - Disability
KW - Multiple sclerosis
KW - Randomized controlled trial
KW - Relapse
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=81255161781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81255161781&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2011.06.035
DO - 10.1016/j.jns.2011.06.035
M3 - Article
C2 - 21762931
AN - SCOPUS:81255161781
SN - 0022-510X
VL - 311
SP - 19
EP - 22
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -