TY - JOUR
T1 - Vitamin D deficiency is associated with significant coronary stenoses in asymptomatic African American chronic cocaine users
AU - Lai, Hong
AU - Fishman, Elliot K.
AU - Gerstenblith, Gary
AU - Brinker, Jeffrey A.
AU - Tong, Wenjing
AU - Bhatia, Sandeepan
AU - Detrick, Barbara
AU - Lai, Shenghan
N1 - Funding Information:
We thank the study participants for their contributions. The study was supported by grants from the National Institute on Drug Abuse, National Institutes of Health ( NIH R01DA12777 , R01DA15020 , and R01DA25524 ). The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [50] .
PY - 2012/7/12
Y1 - 2012/7/12
N2 - Background: Chronic cocaine use may lead to premature atherosclerosis, however, the prevalence of and risk factors for coronary artery disease in asymptomatic cocaine users have not been reported. Methods: Between August 2007 and June 2010, 385 African American chronic cocaine users aged 25 to 54 years were consecutively enrolled in a study to investigate the prevalence of CT angiographically-defined significant (≥ 50%) coronary stenosis and related risk factors. Sociodemographic, drug-use behavior, medical history and medication data were obtained by interview and confirmed by medical chart review. Clinical examinations were performed as well as extensive laboratory tests including those for fasting lipid profiles, HIV, high sensitivity C-reactive protein, and vitamin D. Contrast-enhanced coronary CT angiography was performed. Results: Significant coronary stenosis was detected in 52 of 385 participants (13.5%). The prevalences were 12% and 30% in those with low risk and with middle-high risk Framingham score, respectively. In those with low risk scores, the prevalences of significant stenosis were 10% and 18% in those without and with vitamin D deficiency, defined as serum 25-(OH) vitamin D < 10 ng/mL (p = 0.08). Multiple logistic regression analysis revealed that vitamin D deficiency (adjusted OR = 2.18, 95% CI: 1.07-4.43) is independently associated with the presence of significant coronary stenosis after controlling for traditional risk factors. Conclusions: The study indicates that the prevalence of significant coronary stenoses is high in asymptomatic young and middle-aged African American chronic cocaine users. These findings emphasize the importance of aggressive reduction of risk factors, including vitamin D deficiency in this population.
AB - Background: Chronic cocaine use may lead to premature atherosclerosis, however, the prevalence of and risk factors for coronary artery disease in asymptomatic cocaine users have not been reported. Methods: Between August 2007 and June 2010, 385 African American chronic cocaine users aged 25 to 54 years were consecutively enrolled in a study to investigate the prevalence of CT angiographically-defined significant (≥ 50%) coronary stenosis and related risk factors. Sociodemographic, drug-use behavior, medical history and medication data were obtained by interview and confirmed by medical chart review. Clinical examinations were performed as well as extensive laboratory tests including those for fasting lipid profiles, HIV, high sensitivity C-reactive protein, and vitamin D. Contrast-enhanced coronary CT angiography was performed. Results: Significant coronary stenosis was detected in 52 of 385 participants (13.5%). The prevalences were 12% and 30% in those with low risk and with middle-high risk Framingham score, respectively. In those with low risk scores, the prevalences of significant stenosis were 10% and 18% in those without and with vitamin D deficiency, defined as serum 25-(OH) vitamin D < 10 ng/mL (p = 0.08). Multiple logistic regression analysis revealed that vitamin D deficiency (adjusted OR = 2.18, 95% CI: 1.07-4.43) is independently associated with the presence of significant coronary stenosis after controlling for traditional risk factors. Conclusions: The study indicates that the prevalence of significant coronary stenoses is high in asymptomatic young and middle-aged African American chronic cocaine users. These findings emphasize the importance of aggressive reduction of risk factors, including vitamin D deficiency in this population.
KW - CT coronary angiography
KW - Chronic cocaine use
KW - Significant coronary stenosis
KW - Vitamin D deficiency
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U2 - 10.1016/j.ijcard.2011.01.032
DO - 10.1016/j.ijcard.2011.01.032
M3 - Article
C2 - 21295360
AN - SCOPUS:84862232922
SN - 0167-5273
VL - 158
SP - 211
EP - 216
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 2
ER -