Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: A prospective cohort study

Auyon J. Ghosh; Matthew Moll; Lystra P. Hayden; Jessica Bon; Elizabeth Regan; Craig P. Hersh; James D. Crapo; Edwin K. Silverman; Barry J. Make; Elizabeth A. Regan; Terri Beaty; Ferdouse Begum; Peter J. Castaldi; Michael Cho; Dawn L. Demeo; Adel R. Boueiz; Marilyn G. Foreman; Eitan Halper-Stromberg; Lystra P. Hayden; Jacqueline Hetmanski; Brian D. Hobbs; John E. Hokanson; Nan Laird; Christoph Lange; Sharon M. Lutz; Merry Lynn McDonald; Margaret M. Parker; Dandi Qiao; Elizabeth A. Regan; Edwin K. Silverman; Emily S. Wan; Sungho Won; Phuwanat Sakornsakolpat; Dmitry Prokopenko; Mustafa Al Qaisi; Harvey O. Coxson; Teresa Gray; Meilan K. Han; Eric A. Hoffman; Stephen Humphries; Francine L. Jacobson; Philip F. Judy; Ella A. Kazerooni; Alex Kluiber; David A. Lynch; John D. Newell; Elizabeth A. Regan; James C. Ross; Raul San Jose Estepar; Joyce Schroeder; Jered Sieren; Douglas Stinson; Berend C. Stoel; Juerg Tschirren; Edwin Van Beek; Bram Van Ginneken; Eva Van Rikxoort; George Washko; Carla G. Wilson; Robert Jensen; Douglas Everett; Jim Crooks; Camille Moore; Matt Strand; Carla G. Wilson; John E. Hokanson; John Hughes; Gregory Kinney; Sharon M. Lutz; Katherine Pratte; Kendra A. Young; Surya Bhatt; Jessica Bon; Barry Make; Carlos Martinez; Susan Murray; Elizabeth Regan; Xavier Soler; Carla G. Wilson; Russell P. Bowler; Katerina Kechris; Farnoush Banaei-Kashani; Jeffrey L. Curtis; Carlos H. Martinez; Perry G. Pernicano; Nicola Hanania; Philip Alapat; Mustafa Atik; Venkata Bandi; Aladin Boriek; Kalpatha Guntupalli; Elizabeth Guy; Arun Nachiappan; Amit Parulekar; Dawn L. Demeo; Francine L. Jacobson; R. Graham Barr; John Austin; Belinda D'Souza; Gregory D.N. Pearson; Anna Rozenshtein; Byron Thomashow; Neil MacIntyre; H. Page McAdams; Lacey Washington; Charlene McEvoy; Joseph Tashjian; Robert Wise; Robert Brown; Nadia N. Hansel; Karen Horton; Allison Lambert; Nirupama Putcha; Richard Casaburi; Alessandra Adami; Matthew Budoff; Hans Fischer; Janos Porszasz; Harry Rossiter; William Stringer; Amir Sharafkhaneh; Charlie Lan; Christine Wendt; Brian Bell; Marilyn G. Foreman; Eugene Berkowitz; Gloria Westney; Russell Bowler; David A. Lynch; Richard Rosiello; David Pace; Gerard Criner; David Ciccolella; Francis Cordova; Chandra Dass; Gilbert D'Alonzo; Parag Desai; Michael Jacobs; Steven Kelsen; Victor Kim; A. James Mamary; Nathaniel Marchetti; Aditi Satti; Kartik Shenoy; Robert M. Steiner; Alex Swift; Irene Swift; Maria Elena Vega-Sanchez

doi:10.1186/s12890-020-1148-4

Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: A prospective cohort study

Auyon J. Ghosh, Matthew Moll, Lystra P. Hayden, Jessica Bon, Elizabeth Regan, Craig P. Hersh, James D. Crapo, Edwin K. Silverman, Barry J. Make, Elizabeth A. Regan, Terri Beaty, Ferdouse Begum, Peter J. Castaldi, Michael Cho, Dawn L. Demeo, Adel R. Boueiz, Marilyn G. Foreman, Eitan Halper-Stromberg, Lystra P. Hayden, Jacqueline HetmanskiBrian D. Hobbs, John E. Hokanson, Nan Laird, Christoph Lange, Sharon M. Lutz, Merry Lynn McDonald, Margaret M. Parker, Dandi Qiao, Elizabeth A. Regan, Edwin K. Silverman, Emily S. Wan, Sungho Won, Phuwanat Sakornsakolpat, Dmitry Prokopenko, Mustafa Al Qaisi, Harvey O. Coxson, Teresa Gray, Meilan K. Han, Eric A. Hoffman, Stephen Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, Alex Kluiber, David A. Lynch, John D. Newell, Elizabeth A. Regan, James C. Ross, Raul San Jose Estepar, Joyce Schroeder, Jered Sieren, Douglas Stinson, Berend C. Stoel, Juerg Tschirren, Edwin Van Beek, Bram Van Ginneken, Eva Van Rikxoort, George Washko, Carla G. Wilson, Robert Jensen, Douglas Everett, Jim Crooks, Camille Moore, Matt Strand, Carla G. Wilson, John E. Hokanson, John Hughes, Gregory Kinney, Sharon M. Lutz, Katherine Pratte, Kendra A. Young, Surya Bhatt, Jessica Bon, Barry Make, Carlos Martinez, Susan Murray, Elizabeth Regan, Xavier Soler, Carla G. Wilson, Russell P. Bowler, Katerina Kechris, Farnoush Banaei-Kashani, Jeffrey L. Curtis, Carlos H. Martinez, Perry G. Pernicano, Nicola Hanania, Philip Alapat, Mustafa Atik, Venkata Bandi, Aladin Boriek, Kalpatha Guntupalli, Elizabeth Guy, Arun Nachiappan, Amit Parulekar, Dawn L. Demeo, Francine L. Jacobson, R. Graham Barr, John Austin, Belinda D'Souza, Gregory D.N. Pearson, Anna Rozenshtein, Byron Thomashow, Neil MacIntyre, H. Page McAdams, Lacey Washington, Charlene McEvoy, Joseph Tashjian, Robert Wise, Robert Brown, Nadia N. Hansel, Karen Horton, Allison Lambert, Nirupama Putcha, Richard Casaburi, Alessandra Adami, Matthew Budoff, Hans Fischer, Janos Porszasz, Harry Rossiter, William Stringer, Amir Sharafkhaneh, Charlie Lan, Christine Wendt, Brian Bell, Marilyn G. Foreman, Eugene Berkowitz, Gloria Westney, Russell Bowler, David A. Lynch, Richard Rosiello, David Pace, Gerard Criner, David Ciccolella, Francis Cordova, Chandra Dass, Gilbert D'Alonzo, Parag Desai, Michael Jacobs, Steven Kelsen, Victor Kim, A. James Mamary, Nathaniel Marchetti, Aditi Satti, Kartik Shenoy, Robert M. Steiner, Alex Swift, Irene Swift, Maria Elena Vega-Sanchez

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D levels on imaging characteristics remains mostly unexplored. Using cross-sectional and longitudinal follow up data from the COPDGene Study, we assessed the association between vitamin D levels on respiratory symptoms, exacerbations, and imaging characteristics. We hypothesized that vitamin D deficiency will be associated with worse respiratory-related outcomes. Methods: Current and former smokers between ages 45-80 were enrolled the COPDGene Study. Subjects completed questionnaires, spirometry, six-minute walk test, and chest computed tomography scans. A subset of subjects had measurement of serum concentration of 25-hydroxyvitamin D (25(OH)D). Vitamin D deficiency was defined as serum concentration less than 20 ng/mL. Longitudinal follow up was conducted via a web-based or telephone questionnaire. Results: Vitamin D levels were measured on 1544 current and former smokers, of which 981 subjects had sufficient vitamin D levels and 563 subjects had vitamin D deficiency. Subjects with vitamin D deficiency were younger with increased likelihood of being African American, being current smokers, having a lower percent predicted FEV₁, and having COPD. Vitamin D deficiency was associated with worse quality of life, increased dyspnea, decreased exercise tolerance, and increased frequency of severe exacerbations. Vitamin D deficiency was also associated with increased segmental airway wall thickness on chest CT scans. Conclusion: Vitamin D deficiency was associated with increased respiratory symptoms, decreased functional status, increased frequency of severe exacerbations, as well as airway wall thickening on chest CT scans. Further research is needed to determine the potential impact of vitamin D supplementation to improve disease outcomes.

Original language	English (US)
Article number	123
Journal	BMC pulmonary medicine
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12890-020-1148-4
State	Published - May 4 2020

Keywords

COPD
Quantitative imaging
Respiratory symptoms
Vitamin D

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1186/s12890-020-1148-4

Cite this

Ghosh, A. J., Moll, M., Hayden, L. P., Bon, J., Regan, E., Hersh, C. P., Crapo, J. D., Silverman, E. K., Make, B. J., Regan, E. A., Beaty, T., Begum, F., Castaldi, P. J., Cho, M., Demeo, D. L., Boueiz, A. R., Foreman, M. G., Halper-Stromberg, E., Hayden, L. P., ... Vega-Sanchez, M. E. (2020). Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: A prospective cohort study. BMC pulmonary medicine, 20(1), Article 123. https://doi.org/10.1186/s12890-020-1148-4

Ghosh, AJ, Moll, M, Hayden, LP, Bon, J, Regan, E, Hersh, CP, Crapo, JD, Silverman, EK, Make, BJ, Regan, EA, Beaty, T, Begum, F, Castaldi, PJ, Cho, M, Demeo, DL, Boueiz, AR, Foreman, MG, Halper-Stromberg, E, Hayden, LP, Hetmanski, J, Hobbs, BD, Hokanson, JE, Laird, N, Lange, C, Lutz, SM, McDonald, ML, Parker, MM, Qiao, D, Regan, EA, Silverman, EK, Wan, ES, Won, S, Sakornsakolpat, P, Prokopenko, D, Al Qaisi, M, Coxson, HO, Gray, T, Han, MK, Hoffman, EA, Humphries, S, Jacobson, FL, Judy, PF, Kazerooni, EA, Kluiber, A, Lynch, DA, Newell, JD, Regan, EA, Ross, JC, Estepar, RSJ, Schroeder, J, Sieren, J, Stinson, D, Stoel, BC, Tschirren, J, Van Beek, E, Van Ginneken, B, Van Rikxoort, E, Washko, G, Wilson, CG, Jensen, R, Everett, D, Crooks, J, Moore, C, Strand, M, Wilson, CG, Hokanson, JE, Hughes, J, Kinney, G, Lutz, SM, Pratte, K, Young, KA, Bhatt, S, Bon, J, Make, B, Martinez, C, Murray, S, Regan, E, Soler, X, Wilson, CG, Bowler, RP, Kechris, K, Banaei-Kashani, F, Curtis, JL, Martinez, CH, Pernicano, PG, Hanania, N, Alapat, P, Atik, M, Bandi, V, Boriek, A, Guntupalli, K, Guy, E, Nachiappan, A, Parulekar, A, Demeo, DL, Jacobson, FL, Barr, RG, Austin, J, D'Souza, B, Pearson, GDN, Rozenshtein, A, Thomashow, B, MacIntyre, N, McAdams, HP, Washington, L, McEvoy, C, Tashjian, J, Wise, R , Brown, R , Hansel, NN , Horton, K, Lambert, A, Putcha, N, Casaburi, R, Adami, A, Budoff, M, Fischer, H, Porszasz, J, Rossiter, H, Stringer, W, Sharafkhaneh, A, Lan, C, Wendt, C, Bell, B, Foreman, MG, Berkowitz, E, Westney, G, Bowler, R, Lynch, DA, Rosiello, R, Pace, D, Criner, G, Ciccolella, D, Cordova, F, Dass, C, D'Alonzo, G, Desai, P, Jacobs, M, Kelsen, S, Kim, V, Mamary, AJ, Marchetti, N, Satti, A, Shenoy, K, Steiner, RM, Swift, A, Swift, I & Vega-Sanchez, ME 2020, 'Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: A prospective cohort study', BMC pulmonary medicine, vol. 20, no. 1, 123. https://doi.org/10.1186/s12890-020-1148-4

@article{86942e48007f440cb9a6239724e9e7af,

title = "Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: A prospective cohort study",

abstract = "Background: Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D levels on imaging characteristics remains mostly unexplored. Using cross-sectional and longitudinal follow up data from the COPDGene Study, we assessed the association between vitamin D levels on respiratory symptoms, exacerbations, and imaging characteristics. We hypothesized that vitamin D deficiency will be associated with worse respiratory-related outcomes. Methods: Current and former smokers between ages 45-80 were enrolled the COPDGene Study. Subjects completed questionnaires, spirometry, six-minute walk test, and chest computed tomography scans. A subset of subjects had measurement of serum concentration of 25-hydroxyvitamin D (25(OH)D). Vitamin D deficiency was defined as serum concentration less than 20 ng/mL. Longitudinal follow up was conducted via a web-based or telephone questionnaire. Results: Vitamin D levels were measured on 1544 current and former smokers, of which 981 subjects had sufficient vitamin D levels and 563 subjects had vitamin D deficiency. Subjects with vitamin D deficiency were younger with increased likelihood of being African American, being current smokers, having a lower percent predicted FEV1, and having COPD. Vitamin D deficiency was associated with worse quality of life, increased dyspnea, decreased exercise tolerance, and increased frequency of severe exacerbations. Vitamin D deficiency was also associated with increased segmental airway wall thickness on chest CT scans. Conclusion: Vitamin D deficiency was associated with increased respiratory symptoms, decreased functional status, increased frequency of severe exacerbations, as well as airway wall thickening on chest CT scans. Further research is needed to determine the potential impact of vitamin D supplementation to improve disease outcomes.",

keywords = "COPD, Quantitative imaging, Respiratory symptoms, Vitamin D",

author = "Ghosh, {Auyon J.} and Matthew Moll and Hayden, {Lystra P.} and Jessica Bon and Elizabeth Regan and Hersh, {Craig P.} and Crapo, {James D.} and Silverman, {Edwin K.} and Make, {Barry J.} and Regan, {Elizabeth A.} and Terri Beaty and Ferdouse Begum and Castaldi, {Peter J.} and Michael Cho and Demeo, {Dawn L.} and Boueiz, {Adel R.} and Foreman, {Marilyn G.} and Eitan Halper-Stromberg and Hayden, {Lystra P.} and Jacqueline Hetmanski and Hobbs, {Brian D.} and Hokanson, {John E.} and Nan Laird and Christoph Lange and Lutz, {Sharon M.} and McDonald, {Merry Lynn} and Parker, {Margaret M.} and Dandi Qiao and Regan, {Elizabeth A.} and Silverman, {Edwin K.} and Wan, {Emily S.} and Sungho Won and Phuwanat Sakornsakolpat and Dmitry Prokopenko and {Al Qaisi}, Mustafa and Coxson, {Harvey O.} and Teresa Gray and Han, {Meilan K.} and Hoffman, {Eric A.} and Stephen Humphries and Jacobson, {Francine L.} and Judy, {Philip F.} and Kazerooni, {Ella A.} and Alex Kluiber and Lynch, {David A.} and Newell, {John D.} and Regan, {Elizabeth A.} and Ross, {James C.} and Estepar, {Raul San Jose} and Joyce Schroeder and Jered Sieren and Douglas Stinson and Stoel, {Berend C.} and Juerg Tschirren and {Van Beek}, Edwin and {Van Ginneken}, Bram and {Van Rikxoort}, Eva and George Washko and Wilson, {Carla G.} and Robert Jensen and Douglas Everett and Jim Crooks and Camille Moore and Matt Strand and Wilson, {Carla G.} and Hokanson, {John E.} and John Hughes and Gregory Kinney and Lutz, {Sharon M.} and Katherine Pratte and Young, {Kendra A.} and Surya Bhatt and Jessica Bon and Barry Make and Carlos Martinez and Susan Murray and Elizabeth Regan and Xavier Soler and Wilson, {Carla G.} and Bowler, {Russell P.} and Katerina Kechris and Farnoush Banaei-Kashani and Curtis, {Jeffrey L.} and Martinez, {Carlos H.} and Pernicano, {Perry G.} and Nicola Hanania and Philip Alapat and Mustafa Atik and Venkata Bandi and Aladin Boriek and Kalpatha Guntupalli and Elizabeth Guy and Arun Nachiappan and Amit Parulekar and Demeo, {Dawn L.} and Jacobson, {Francine L.} and Barr, {R. Graham} and John Austin and Belinda D'Souza and Pearson, {Gregory D.N.} and Anna Rozenshtein and Byron Thomashow and Neil MacIntyre and McAdams, {H. Page} and Lacey Washington and Charlene McEvoy and Joseph Tashjian and Robert Wise and Robert Brown and Hansel, {Nadia N.} and Karen Horton and Allison Lambert and Nirupama Putcha and Richard Casaburi and Alessandra Adami and Matthew Budoff and Hans Fischer and Janos Porszasz and Harry Rossiter and William Stringer and Amir Sharafkhaneh and Charlie Lan and Christine Wendt and Brian Bell and Foreman, {Marilyn G.} and Eugene Berkowitz and Gloria Westney and Russell Bowler and Lynch, {David A.} and Richard Rosiello and David Pace and Gerard Criner and David Ciccolella and Francis Cordova and Chandra Dass and Gilbert D'Alonzo and Parag Desai and Michael Jacobs and Steven Kelsen and Victor Kim and Mamary, {A. James} and Nathaniel Marchetti and Aditi Satti and Kartik Shenoy and Steiner, {Robert M.} and Alex Swift and Irene Swift and Vega-Sanchez, {Maria Elena}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",

year = "2020",

month = may,

day = "4",

doi = "10.1186/s12890-020-1148-4",

language = "English (US)",

volume = "20",

journal = "BMC pulmonary medicine",

issn = "1471-2466",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD

T2 - A prospective cohort study

AU - Ghosh, Auyon J.

AU - Moll, Matthew

AU - Hayden, Lystra P.

AU - Bon, Jessica

AU - Regan, Elizabeth

AU - Hersh, Craig P.

AU - Crapo, James D.

AU - Silverman, Edwin K.

AU - Make, Barry J.

AU - Regan, Elizabeth A.

AU - Beaty, Terri

AU - Begum, Ferdouse

AU - Castaldi, Peter J.

AU - Cho, Michael

AU - Demeo, Dawn L.

AU - Boueiz, Adel R.

AU - Foreman, Marilyn G.

AU - Halper-Stromberg, Eitan

AU - Hayden, Lystra P.

AU - Hetmanski, Jacqueline

AU - Hobbs, Brian D.

AU - Hokanson, John E.

AU - Laird, Nan

AU - Lange, Christoph

AU - Lutz, Sharon M.

AU - McDonald, Merry Lynn

AU - Parker, Margaret M.

AU - Qiao, Dandi

AU - Regan, Elizabeth A.

AU - Silverman, Edwin K.

AU - Wan, Emily S.

AU - Won, Sungho

AU - Sakornsakolpat, Phuwanat

AU - Prokopenko, Dmitry

AU - Al Qaisi, Mustafa

AU - Coxson, Harvey O.

AU - Gray, Teresa

AU - Han, Meilan K.

AU - Hoffman, Eric A.

AU - Humphries, Stephen

AU - Jacobson, Francine L.

AU - Judy, Philip F.

AU - Kazerooni, Ella A.

AU - Kluiber, Alex

AU - Lynch, David A.

AU - Newell, John D.

AU - Regan, Elizabeth A.

AU - Ross, James C.

AU - Estepar, Raul San Jose

AU - Schroeder, Joyce

AU - Sieren, Jered

AU - Stinson, Douglas

AU - Stoel, Berend C.

AU - Tschirren, Juerg

AU - Van Beek, Edwin

AU - Van Ginneken, Bram

AU - Van Rikxoort, Eva

AU - Washko, George

AU - Wilson, Carla G.

AU - Jensen, Robert

AU - Everett, Douglas

AU - Crooks, Jim

AU - Moore, Camille

AU - Strand, Matt

AU - Wilson, Carla G.

AU - Hokanson, John E.

AU - Hughes, John

AU - Kinney, Gregory

AU - Lutz, Sharon M.

AU - Pratte, Katherine

AU - Young, Kendra A.

AU - Bhatt, Surya

AU - Bon, Jessica

AU - Make, Barry

AU - Martinez, Carlos

AU - Murray, Susan

AU - Regan, Elizabeth

AU - Soler, Xavier

AU - Wilson, Carla G.

AU - Bowler, Russell P.

AU - Kechris, Katerina

AU - Banaei-Kashani, Farnoush

AU - Curtis, Jeffrey L.

AU - Martinez, Carlos H.

AU - Pernicano, Perry G.

AU - Hanania, Nicola

AU - Alapat, Philip

AU - Atik, Mustafa

AU - Bandi, Venkata

AU - Boriek, Aladin

AU - Guntupalli, Kalpatha

AU - Guy, Elizabeth

AU - Nachiappan, Arun

AU - Parulekar, Amit

AU - Demeo, Dawn L.

AU - Jacobson, Francine L.

AU - Barr, R. Graham

AU - Austin, John

AU - D'Souza, Belinda

AU - Pearson, Gregory D.N.

AU - Rozenshtein, Anna

AU - Thomashow, Byron

AU - MacIntyre, Neil

AU - McAdams, H. Page

AU - Washington, Lacey

AU - McEvoy, Charlene

AU - Tashjian, Joseph

AU - Wise, Robert

AU - Brown, Robert

AU - Hansel, Nadia N.

AU - Horton, Karen

AU - Lambert, Allison

AU - Putcha, Nirupama

AU - Casaburi, Richard

AU - Adami, Alessandra

AU - Budoff, Matthew

AU - Fischer, Hans

AU - Porszasz, Janos

AU - Rossiter, Harry

AU - Stringer, William

AU - Sharafkhaneh, Amir

AU - Lan, Charlie

AU - Wendt, Christine

AU - Bell, Brian

AU - Foreman, Marilyn G.

AU - Berkowitz, Eugene

AU - Westney, Gloria

AU - Bowler, Russell

AU - Lynch, David A.

AU - Rosiello, Richard

AU - Pace, David

AU - Criner, Gerard

AU - Ciccolella, David

AU - Cordova, Francis

AU - Dass, Chandra

AU - D'Alonzo, Gilbert

AU - Desai, Parag

AU - Jacobs, Michael

AU - Kelsen, Steven

AU - Kim, Victor

AU - Mamary, A. James

AU - Marchetti, Nathaniel

AU - Satti, Aditi

AU - Shenoy, Kartik

AU - Steiner, Robert M.

AU - Swift, Alex

AU - Swift, Irene

AU - Vega-Sanchez, Maria Elena

PY - 2020/5/4

Y1 - 2020/5/4

N2 - Background: Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D levels on imaging characteristics remains mostly unexplored. Using cross-sectional and longitudinal follow up data from the COPDGene Study, we assessed the association between vitamin D levels on respiratory symptoms, exacerbations, and imaging characteristics. We hypothesized that vitamin D deficiency will be associated with worse respiratory-related outcomes. Methods: Current and former smokers between ages 45-80 were enrolled the COPDGene Study. Subjects completed questionnaires, spirometry, six-minute walk test, and chest computed tomography scans. A subset of subjects had measurement of serum concentration of 25-hydroxyvitamin D (25(OH)D). Vitamin D deficiency was defined as serum concentration less than 20 ng/mL. Longitudinal follow up was conducted via a web-based or telephone questionnaire. Results: Vitamin D levels were measured on 1544 current and former smokers, of which 981 subjects had sufficient vitamin D levels and 563 subjects had vitamin D deficiency. Subjects with vitamin D deficiency were younger with increased likelihood of being African American, being current smokers, having a lower percent predicted FEV1, and having COPD. Vitamin D deficiency was associated with worse quality of life, increased dyspnea, decreased exercise tolerance, and increased frequency of severe exacerbations. Vitamin D deficiency was also associated with increased segmental airway wall thickness on chest CT scans. Conclusion: Vitamin D deficiency was associated with increased respiratory symptoms, decreased functional status, increased frequency of severe exacerbations, as well as airway wall thickening on chest CT scans. Further research is needed to determine the potential impact of vitamin D supplementation to improve disease outcomes.

AB - Background: Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D levels on imaging characteristics remains mostly unexplored. Using cross-sectional and longitudinal follow up data from the COPDGene Study, we assessed the association between vitamin D levels on respiratory symptoms, exacerbations, and imaging characteristics. We hypothesized that vitamin D deficiency will be associated with worse respiratory-related outcomes. Methods: Current and former smokers between ages 45-80 were enrolled the COPDGene Study. Subjects completed questionnaires, spirometry, six-minute walk test, and chest computed tomography scans. A subset of subjects had measurement of serum concentration of 25-hydroxyvitamin D (25(OH)D). Vitamin D deficiency was defined as serum concentration less than 20 ng/mL. Longitudinal follow up was conducted via a web-based or telephone questionnaire. Results: Vitamin D levels were measured on 1544 current and former smokers, of which 981 subjects had sufficient vitamin D levels and 563 subjects had vitamin D deficiency. Subjects with vitamin D deficiency were younger with increased likelihood of being African American, being current smokers, having a lower percent predicted FEV1, and having COPD. Vitamin D deficiency was associated with worse quality of life, increased dyspnea, decreased exercise tolerance, and increased frequency of severe exacerbations. Vitamin D deficiency was also associated with increased segmental airway wall thickness on chest CT scans. Conclusion: Vitamin D deficiency was associated with increased respiratory symptoms, decreased functional status, increased frequency of severe exacerbations, as well as airway wall thickening on chest CT scans. Further research is needed to determine the potential impact of vitamin D supplementation to improve disease outcomes.

KW - COPD

KW - Quantitative imaging

KW - Respiratory symptoms

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=85084277182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85084277182&partnerID=8YFLogxK

U2 - 10.1186/s12890-020-1148-4

DO - 10.1186/s12890-020-1148-4

M3 - Article

C2 - 32366316

AN - SCOPUS:85084277182

SN - 1471-2466

VL - 20

JO - BMC pulmonary medicine

JF - BMC pulmonary medicine

IS - 1

M1 - 123

ER -

Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: A prospective cohort study

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