Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T-cell lymphoma

Seok Jin Kim, Cheng Shu, Kyung Ju Ryu, Danbee Kang, Juhee Cho, Young Hyeh Ko, Soo Youn Lee, Eliseo Guallar, Weili Zhao, Won Seog Kim

Research output: Contribution to journalArticle

Abstract

Vitamin D deficiency is a common health issue; however, the effect of vitamin D deficiency on the survival of T-cell lymphoma is still not clear. We evaluated the impact of serum vitamin D level of patients with peripheral T-cell lymphoma (PTCL) and extranodal natural killer/T-cell lymphoma (ENKTL) on survival outcome. Pretreatment levels of 25-hydroxyvitamin D [25(OH)D] and inflammatory cytokines were measured in serum samples that were archived at diagnosis, and we evaluated their association with survival in newly diagnosed patients with PTCL (n = 137) and ENKTL (n = 114) at a university-based hospital in Korea. An independent cohort from Rui Jin Hospital (Shanghai, China) was used for validation. The median 25(OH)D serum level was 12.0 ng/mL (1.3-60.0 ng/mL), and 40% had less than 10 ng/mL, which was defined as vitamin D deficiency. Median serum 25(OH)D levels were similar between PTCL (11.5 ng/mL) and ENKTL (12.9 ng/mL); however, vitamin D deficiency was associated with inferior survival in ENKTL but not with PTCL. The independent validation cohort (n = 115) also showed a significant association of vitamin D deficiency with poor survival in ENKTL. The 25(OH)D level had an inverse relation with inflammatory cytokines; this association had a negative effect only on survival of ENKTL, and not on PTCL. In conclusion, vitamin D deficiency was associated with inferior survival outcome of patients with ENKTL.

Original languageEnglish (US)
Pages (from-to)3971-3980
Number of pages10
JournalCancer Science
Volume109
Issue number12
DOIs
StatePublished - Dec 1 2018

Fingerprint

Natural Killer T-Cells
Vitamin D Deficiency
T-Cell Lymphoma
Peripheral T-Cell Lymphoma
Survival
Serum
Cytokines
Korea
Vitamin D
China
Health

Keywords

  • chemotherapy
  • NK/T-cell lymphoma
  • prognosis
  • survival
  • vitamin D

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kim, S. J., Shu, C., Ryu, K. J., Kang, D., Cho, J., Ko, Y. H., ... Kim, W. S. (2018). Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T-cell lymphoma. Cancer Science, 109(12), 3971-3980. https://doi.org/10.1111/cas.13844

Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T-cell lymphoma. / Kim, Seok Jin; Shu, Cheng; Ryu, Kyung Ju; Kang, Danbee; Cho, Juhee; Ko, Young Hyeh; Lee, Soo Youn; Guallar, Eliseo; Zhao, Weili; Kim, Won Seog.

In: Cancer Science, Vol. 109, No. 12, 01.12.2018, p. 3971-3980.

Research output: Contribution to journalArticle

Kim, SJ, Shu, C, Ryu, KJ, Kang, D, Cho, J, Ko, YH, Lee, SY, Guallar, E, Zhao, W & Kim, WS 2018, 'Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T-cell lymphoma', Cancer Science, vol. 109, no. 12, pp. 3971-3980. https://doi.org/10.1111/cas.13844
Kim, Seok Jin ; Shu, Cheng ; Ryu, Kyung Ju ; Kang, Danbee ; Cho, Juhee ; Ko, Young Hyeh ; Lee, Soo Youn ; Guallar, Eliseo ; Zhao, Weili ; Kim, Won Seog. / Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T-cell lymphoma. In: Cancer Science. 2018 ; Vol. 109, No. 12. pp. 3971-3980.
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