Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T-cell lymphoma

Seok Jin Kim, Cheng Shu, Kyung Ju Ryu, Danbee Kang, Juhee Cho, Young Hyeh Ko, Soo Youn Lee, Eliseo Guallar, Weili Zhao, Won Seog Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Vitamin D deficiency is a common health issue; however, the effect of vitamin D deficiency on the survival of T-cell lymphoma is still not clear. We evaluated the impact of serum vitamin D level of patients with peripheral T-cell lymphoma (PTCL) and extranodal natural killer/T-cell lymphoma (ENKTL) on survival outcome. Pretreatment levels of 25-hydroxyvitamin D [25(OH)D] and inflammatory cytokines were measured in serum samples that were archived at diagnosis, and we evaluated their association with survival in newly diagnosed patients with PTCL (n = 137) and ENKTL (n = 114) at a university-based hospital in Korea. An independent cohort from Rui Jin Hospital (Shanghai, China) was used for validation. The median 25(OH)D serum level was 12.0 ng/mL (1.3-60.0 ng/mL), and 40% had less than 10 ng/mL, which was defined as vitamin D deficiency. Median serum 25(OH)D levels were similar between PTCL (11.5 ng/mL) and ENKTL (12.9 ng/mL); however, vitamin D deficiency was associated with inferior survival in ENKTL but not with PTCL. The independent validation cohort (n = 115) also showed a significant association of vitamin D deficiency with poor survival in ENKTL. The 25(OH)D level had an inverse relation with inflammatory cytokines; this association had a negative effect only on survival of ENKTL, and not on PTCL. In conclusion, vitamin D deficiency was associated with inferior survival outcome of patients with ENKTL.

Original languageEnglish (US)
Pages (from-to)3971-3980
Number of pages10
JournalCancer Science
Volume109
Issue number12
DOIs
StatePublished - Dec 1 2018

Keywords

  • chemotherapy
  • NK/T-cell lymphoma
  • prognosis
  • survival
  • vitamin D

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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