Vitamin D deficiency and persistent proteinuria among HIV-infected and uninfected injection drug users

Research output: Contribution to journalArticle

Abstract

Objective: Proteinuria occurs commonly among HIV-infected and uninfected injection drug users (IDUs) and is associated with increased mortality risk. Vitamin D deficiency, highly prevalent among IDUs and potentially modifiable, may contribute to proteinuria. To determine whether vitamin D is associated with proteinuria in this population, we conducted a cross-sectional study in the AIDS Linked to the IntraVenous Experience (ALIVE) Study. Methods: 25(OH)-vitamin D levels were measured in 268 HIV-infected and 614 HIV-uninfected participants. The association between vitamin D deficiency (200mg/g on two occasions) associated with vitamin D deficiency was examined using logistic regression. Results: One-third of participants were vitamin D-deficient. Vitamin D deficiency was independently associated with higher urinary protein excretion (P

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalAIDS
Volume26
Issue number3
DOIs
StatePublished - Jan 28 2012

Fingerprint

Vitamin D Deficiency
Drug Users
Proteinuria
Vitamin D
HIV
Injections
Acquired Immunodeficiency Syndrome
Cross-Sectional Studies
Logistic Models
Mortality
Population
Proteins

Keywords

  • diabetes
  • HIV
  • injection drug use
  • proteinuria
  • vitamin D deficiency

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

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abstract = "Objective: Proteinuria occurs commonly among HIV-infected and uninfected injection drug users (IDUs) and is associated with increased mortality risk. Vitamin D deficiency, highly prevalent among IDUs and potentially modifiable, may contribute to proteinuria. To determine whether vitamin D is associated with proteinuria in this population, we conducted a cross-sectional study in the AIDS Linked to the IntraVenous Experience (ALIVE) Study. Methods: 25(OH)-vitamin D levels were measured in 268 HIV-infected and 614 HIV-uninfected participants. The association between vitamin D deficiency (200mg/g on two occasions) associated with vitamin D deficiency was examined using logistic regression. Results: One-third of participants were vitamin D-deficient. Vitamin D deficiency was independently associated with higher urinary protein excretion (P",
keywords = "diabetes, HIV, injection drug use, proteinuria, vitamin D deficiency",
author = "Estrella, {Michelle M.} and Kirk, {Gregory D} and Mehta, {Shruti Hemendra} and Brown, {Todd T} and Fine, {Derek M} and Mohamed Atta and Lucas, {Gregory M}",
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T1 - Vitamin D deficiency and persistent proteinuria among HIV-infected and uninfected injection drug users

AU - Estrella, Michelle M.

AU - Kirk, Gregory D

AU - Mehta, Shruti Hemendra

AU - Brown, Todd T

AU - Fine, Derek M

AU - Atta, Mohamed

AU - Lucas, Gregory M

PY - 2012/1/28

Y1 - 2012/1/28

N2 - Objective: Proteinuria occurs commonly among HIV-infected and uninfected injection drug users (IDUs) and is associated with increased mortality risk. Vitamin D deficiency, highly prevalent among IDUs and potentially modifiable, may contribute to proteinuria. To determine whether vitamin D is associated with proteinuria in this population, we conducted a cross-sectional study in the AIDS Linked to the IntraVenous Experience (ALIVE) Study. Methods: 25(OH)-vitamin D levels were measured in 268 HIV-infected and 614 HIV-uninfected participants. The association between vitamin D deficiency (200mg/g on two occasions) associated with vitamin D deficiency was examined using logistic regression. Results: One-third of participants were vitamin D-deficient. Vitamin D deficiency was independently associated with higher urinary protein excretion (P

AB - Objective: Proteinuria occurs commonly among HIV-infected and uninfected injection drug users (IDUs) and is associated with increased mortality risk. Vitamin D deficiency, highly prevalent among IDUs and potentially modifiable, may contribute to proteinuria. To determine whether vitamin D is associated with proteinuria in this population, we conducted a cross-sectional study in the AIDS Linked to the IntraVenous Experience (ALIVE) Study. Methods: 25(OH)-vitamin D levels were measured in 268 HIV-infected and 614 HIV-uninfected participants. The association between vitamin D deficiency (200mg/g on two occasions) associated with vitamin D deficiency was examined using logistic regression. Results: One-third of participants were vitamin D-deficient. Vitamin D deficiency was independently associated with higher urinary protein excretion (P

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