Vitamin D: Beyond bone

Sylvia Christakos, Martin Hewison, David G. Gardner, Carol L. Wagner, Igor N. Sergeev, Erica Rutten, Anastassios G. Pittas, Ricardo Boland, Luigi Ferrucci, Daniel D. Bikle

Research output: Contribution to journalArticle

Abstract

In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells. However, the biological significance of the expression of the VDR in different tissues is not fully understood, and the role of vitamin D in extraskeletal health has been a matter of debate. This report summarizes recent research on the roles for vitamin D in cancer, immunity and autoimmune diseases, cardiovascular and respiratory health, pregnancy, obesity, erythropoiesis, diabetes, muscle function, and aging.

Original languageEnglish (US)
Pages (from-to)45-58
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume1287
Issue number1
DOIs
StatePublished - May 2013
Externally publishedYes

Fingerprint

Vitamin D
Bone
Bone and Bones
Health
Calcitriol Receptors
Rickets
Vitamin D Deficiency
Tissue
Erythropoiesis
Bone Diseases
Skin Neoplasms
T-cells
Pancreatic Neoplasms
Developed Countries
Colonic Neoplasms
Placenta
Autoimmune Diseases
Minerals
Medical problems
Immunity

Keywords

  • Aging
  • Cancer
  • Cognitive function
  • Diabetes
  • Immunity
  • Muscle
  • Obesity
  • Pregnancy
  • Pulmonary disease
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Christakos, S., Hewison, M., Gardner, D. G., Wagner, C. L., Sergeev, I. N., Rutten, E., ... Bikle, D. D. (2013). Vitamin D: Beyond bone. Annals of the New York Academy of Sciences, 1287(1), 45-58. https://doi.org/10.1111/nyas.12129

Vitamin D : Beyond bone. / Christakos, Sylvia; Hewison, Martin; Gardner, David G.; Wagner, Carol L.; Sergeev, Igor N.; Rutten, Erica; Pittas, Anastassios G.; Boland, Ricardo; Ferrucci, Luigi; Bikle, Daniel D.

In: Annals of the New York Academy of Sciences, Vol. 1287, No. 1, 05.2013, p. 45-58.

Research output: Contribution to journalArticle

Christakos, S, Hewison, M, Gardner, DG, Wagner, CL, Sergeev, IN, Rutten, E, Pittas, AG, Boland, R, Ferrucci, L & Bikle, DD 2013, 'Vitamin D: Beyond bone', Annals of the New York Academy of Sciences, vol. 1287, no. 1, pp. 45-58. https://doi.org/10.1111/nyas.12129
Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E et al. Vitamin D: Beyond bone. Annals of the New York Academy of Sciences. 2013 May;1287(1):45-58. https://doi.org/10.1111/nyas.12129
Christakos, Sylvia ; Hewison, Martin ; Gardner, David G. ; Wagner, Carol L. ; Sergeev, Igor N. ; Rutten, Erica ; Pittas, Anastassios G. ; Boland, Ricardo ; Ferrucci, Luigi ; Bikle, Daniel D. / Vitamin D : Beyond bone. In: Annals of the New York Academy of Sciences. 2013 ; Vol. 1287, No. 1. pp. 45-58.
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