Vitamin D and risk of neuroimaging abnormalities

Thomas J. Littlejohns, Katarina Kos, William E. Henley, Iain A. Lang, Cedric Annweiler, Olivier Beauchet, Paulo H M Chaves, Bryan R. Kestenbaum, Lewis H. Kuller, Kenneth M. Langa, Oscar L. Lopez, David J. Llewellyn

Research output: Contribution to journalArticle


Vitamin D deficiency has been linked with an increased risk of incident all-cause dementia and Alzheimer's disease. The aim of the current study was to explore the potential mechanisms underlying these associations by determining whether low vitamin D concentrations are associated with the development of incident cerebrovascular and neurodegenerative neuroimaging abnormalities. The population consisted of 1,658 participants aged ≥65 years from the US-based Cardiovascular Health Study who were free from prevalent cardiovascular disease, stroke and dementia at baseline in 1992-93. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected at baseline. The first MRI scan was conducted between 1991-1994 and the second MRI scan was conducted between 1997-1999. Change in white matter grade, ventricular grade and presence of infarcts between MRI scan one and two were used to define neuroimaging abnormalities. During a mean follow-up of 5.0 years, serum 25(OH)D status was not significantly associated with the development of any neuroimaging abnormalities. Using logistic regression models, the multivariate adjusted odds ratios (95% confidence interval) for worsening white matter grade in participants who were severely 25(OH)D deficient (

Original languageEnglish (US)
Article numbere0154896
JournalPLoS One
Issue number5
Publication statusPublished - May 1 2016
Externally publishedYes


ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Littlejohns, T. J., Kos, K., Henley, W. E., Lang, I. A., Annweiler, C., Beauchet, O., ... Llewellyn, D. J. (2016). Vitamin D and risk of neuroimaging abnormalities. PLoS One, 11(5), [e0154896].