TY - JOUR
T1 - Vitamin D and risk of cognitive decline in elderly persons
AU - Llewellyn, David J.
AU - Lang, Iain A.
AU - Langa, Kenneth M.
AU - Muniz-Terrera, Graciela
AU - Phillips, Caroline L.
AU - Cherubini, Antonio
AU - Ferrucci, Luigi
AU - Melzer, David
PY - 2010/7/12
Y1 - 2010/7/12
N2 - Background: To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia. Methods: We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population-based study conducted in Italy between 1998 and 2006 with follow-up assessments every 3 years. A total of 858 adults 65 years or older completed interviews, cognitive assessments, and medical examinations and provided blood samples. Cognitive decline was assessed using the Mini-Mental State Examination (MMSE), and substantial decline was defined as 3 or more points. The Trail-Making Tests A and B were also used, and substantial decline was defined as the worst 10% of the distribution of decline or as discontinued testing. Results: The multivariate adjusted relative risk (95% confidence interval [CI]) of substantial cognitive decline on the MMSE in participants who were severely serum 25 (OH)D deficient (levels
AB - Background: To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia. Methods: We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population-based study conducted in Italy between 1998 and 2006 with follow-up assessments every 3 years. A total of 858 adults 65 years or older completed interviews, cognitive assessments, and medical examinations and provided blood samples. Cognitive decline was assessed using the Mini-Mental State Examination (MMSE), and substantial decline was defined as 3 or more points. The Trail-Making Tests A and B were also used, and substantial decline was defined as the worst 10% of the distribution of decline or as discontinued testing. Results: The multivariate adjusted relative risk (95% confidence interval [CI]) of substantial cognitive decline on the MMSE in participants who were severely serum 25 (OH)D deficient (levels
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U2 - 10.1001/archinternmed.2010.173
DO - 10.1001/archinternmed.2010.173
M3 - Article
C2 - 20625021
AN - SCOPUS:77954600272
SN - 0003-9926
VL - 170
SP - 1135
EP - 1141
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 13
ER -