Vitamin D and its role in cancer and immunity: A prescription for sunlight

Gerard E. Mullin; Adrian Dobs

doi:10.1177/0115426507022003305

Vitamin D and its role in cancer and immunity: A prescription for sunlight

Gerard E. Mullin, Adrian Dobs

School of Medicine

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

Vitamin D has been recognized for more than a century as essential for the normal development and mineralization of a healthy skeleton. More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. VDR has been discovered in most tissues and cells in the body and is able to elicit a wide variety of biologic responses. These observations have been the impetus for a reevaluation of the physiologic and pharmacologic actions of vitamin D. Here, we review the role of vitamin D in regulation of the immune system and its possible role in the prevention and treatment of cancer and immune-mediated diseases.

Original language	English (US)
Pages (from-to)	305-322
Number of pages	18
Journal	Nutrition in Clinical Practice
Volume	22
Issue number	3
DOIs	https://doi.org/10.1177/0115426507022003305
State	Published - 2007

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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title = "Vitamin D and its role in cancer and immunity: A prescription for sunlight",

abstract = "Vitamin D has been recognized for more than a century as essential for the normal development and mineralization of a healthy skeleton. More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. VDR has been discovered in most tissues and cells in the body and is able to elicit a wide variety of biologic responses. These observations have been the impetus for a reevaluation of the physiologic and pharmacologic actions of vitamin D. Here, we review the role of vitamin D in regulation of the immune system and its possible role in the prevention and treatment of cancer and immune-mediated diseases.",

author = "Mullin, {Gerard E.} and Adrian Dobs",

note = "Funding Information: The authors acknowledge Kerry Schulze, PhD, Johns Hopkins School of Public Health, Department of Human Nutrition, and Susan Kreimer, MS, a freelance medical writer in New York, for their editorial contributions. The work was supported in part by grant number AT00437 from the National Center for Complementary & Alternative Medicine of the National Institutes of Health (Adrian S. Dobs, MD, MHS, principal investigator).",

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AU - Dobs, Adrian

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PY - 2007

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N2 - Vitamin D has been recognized for more than a century as essential for the normal development and mineralization of a healthy skeleton. More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. VDR has been discovered in most tissues and cells in the body and is able to elicit a wide variety of biologic responses. These observations have been the impetus for a reevaluation of the physiologic and pharmacologic actions of vitamin D. Here, we review the role of vitamin D in regulation of the immune system and its possible role in the prevention and treatment of cancer and immune-mediated diseases.

AB - Vitamin D has been recognized for more than a century as essential for the normal development and mineralization of a healthy skeleton. More extensive roles for vitamin D were suggested by the discovery of the vitamin D receptor (VDR) in tissues that are not involved in calcium and phosphate metabolism. VDR has been discovered in most tissues and cells in the body and is able to elicit a wide variety of biologic responses. These observations have been the impetus for a reevaluation of the physiologic and pharmacologic actions of vitamin D. Here, we review the role of vitamin D in regulation of the immune system and its possible role in the prevention and treatment of cancer and immune-mediated diseases.

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Vitamin D and its role in cancer and immunity: A prescription for sunlight

Abstract

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