Vitamin D and cognitive function and dementia risk in a biracial cohort: The ARIC Brain MRI Study

A. L C Schneider, P. L. Lutsey, A. Alonso, Rebecca F Gottesman, A. R. Sharrett, Kathryn Anne Carson, M. Gross, Wendy S Post, D. S. Knopman, T. H. Mosley, Erin Donnelly Michos

Research output: Contribution to journalArticle

Abstract

Background and purpose: Some recent studies in older, largely white populations suggest that vitamin D, measured by 25-hydroxyvitamin D [25(OH)D], is important for cognition, but such results may be affected by reverse causation. Measuring 25(OH)D in late middle age before poor cognition affects behavior may provide clearer results. Methods: This was a prospective cohort analysis of 1652 participants (52% white, 48% black) in the Atherosclerosis Risk in Communities (ARIC) Brain MRI Study. 25(OH)D was measured from serum collected in 1993-1995. Cognition was measured by the delayed word recall test (DWRT), the digit symbol substitution test (DSST) and the word fluency test (WFT). Dementia hospitalization was defined by ICD-9 codes. Adjusted linear, logistic and Cox proportional hazards models were used. Results: Mean age of participants was 62 years and 60% were female. Mean 25(OH)D was higher in whites than blacks (25.5 vs. 17.3 ng/ml, P  0.05). Over a median of 16.6 years, there were 145 incident hospitalized dementia cases. Although not statistically significant, lower levels of 25(OH)D were suggestive of an association with increased dementia risk [hazard ratio for lowest versus highest race-specific tertile: whites 1.32 (95% confidence interval 0.69, 2.55); blacks 1.53 (95% confidence interval 0.84, 2.79)]. Conclusions: In contrast to prior studies performed in older white populations, our study of late middle age white and black participants did not find significant associations between lower levels of 25(OH)D with lower cognitive test scores at baseline, change in scores over time or dementia risk.

Original languageEnglish (US)
JournalEuropean Journal of Neurology
Volume21
Issue number9
DOIs
StatePublished - 2014

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Vitamin D
Cognition
Dementia
Atherosclerosis
Brain
International Classification of Diseases
Confidence Intervals
Proportional Hazards Models
Causality
Population
Hospitalization
Cohort Studies
Odds Ratio
Serum
hydroquinone

Keywords

  • ARIC study
  • Cognition
  • Dementia
  • Vitamin D

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Vitamin D and cognitive function and dementia risk in a biracial cohort : The ARIC Brain MRI Study. / Schneider, A. L C; Lutsey, P. L.; Alonso, A.; Gottesman, Rebecca F; Sharrett, A. R.; Carson, Kathryn Anne; Gross, M.; Post, Wendy S; Knopman, D. S.; Mosley, T. H.; Michos, Erin Donnelly.

In: European Journal of Neurology, Vol. 21, No. 9, 2014.

Research output: Contribution to journalArticle

Schneider, A. L C ; Lutsey, P. L. ; Alonso, A. ; Gottesman, Rebecca F ; Sharrett, A. R. ; Carson, Kathryn Anne ; Gross, M. ; Post, Wendy S ; Knopman, D. S. ; Mosley, T. H. ; Michos, Erin Donnelly. / Vitamin D and cognitive function and dementia risk in a biracial cohort : The ARIC Brain MRI Study. In: European Journal of Neurology. 2014 ; Vol. 21, No. 9.
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abstract = "Background and purpose: Some recent studies in older, largely white populations suggest that vitamin D, measured by 25-hydroxyvitamin D [25(OH)D], is important for cognition, but such results may be affected by reverse causation. Measuring 25(OH)D in late middle age before poor cognition affects behavior may provide clearer results. Methods: This was a prospective cohort analysis of 1652 participants (52{\%} white, 48{\%} black) in the Atherosclerosis Risk in Communities (ARIC) Brain MRI Study. 25(OH)D was measured from serum collected in 1993-1995. Cognition was measured by the delayed word recall test (DWRT), the digit symbol substitution test (DSST) and the word fluency test (WFT). Dementia hospitalization was defined by ICD-9 codes. Adjusted linear, logistic and Cox proportional hazards models were used. Results: Mean age of participants was 62 years and 60{\%} were female. Mean 25(OH)D was higher in whites than blacks (25.5 vs. 17.3 ng/ml, P  0.05). Over a median of 16.6 years, there were 145 incident hospitalized dementia cases. Although not statistically significant, lower levels of 25(OH)D were suggestive of an association with increased dementia risk [hazard ratio for lowest versus highest race-specific tertile: whites 1.32 (95{\%} confidence interval 0.69, 2.55); blacks 1.53 (95{\%} confidence interval 0.84, 2.79)]. Conclusions: In contrast to prior studies performed in older white populations, our study of late middle age white and black participants did not find significant associations between lower levels of 25(OH)D with lower cognitive test scores at baseline, change in scores over time or dementia risk.",
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AU - Schneider, A. L C

AU - Lutsey, P. L.

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AU - Gottesman, Rebecca F

AU - Sharrett, A. R.

AU - Carson, Kathryn Anne

AU - Gross, M.

AU - Post, Wendy S

AU - Knopman, D. S.

AU - Mosley, T. H.

AU - Michos, Erin Donnelly

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AB - Background and purpose: Some recent studies in older, largely white populations suggest that vitamin D, measured by 25-hydroxyvitamin D [25(OH)D], is important for cognition, but such results may be affected by reverse causation. Measuring 25(OH)D in late middle age before poor cognition affects behavior may provide clearer results. Methods: This was a prospective cohort analysis of 1652 participants (52% white, 48% black) in the Atherosclerosis Risk in Communities (ARIC) Brain MRI Study. 25(OH)D was measured from serum collected in 1993-1995. Cognition was measured by the delayed word recall test (DWRT), the digit symbol substitution test (DSST) and the word fluency test (WFT). Dementia hospitalization was defined by ICD-9 codes. Adjusted linear, logistic and Cox proportional hazards models were used. Results: Mean age of participants was 62 years and 60% were female. Mean 25(OH)D was higher in whites than blacks (25.5 vs. 17.3 ng/ml, P  0.05). Over a median of 16.6 years, there were 145 incident hospitalized dementia cases. Although not statistically significant, lower levels of 25(OH)D were suggestive of an association with increased dementia risk [hazard ratio for lowest versus highest race-specific tertile: whites 1.32 (95% confidence interval 0.69, 2.55); blacks 1.53 (95% confidence interval 0.84, 2.79)]. Conclusions: In contrast to prior studies performed in older white populations, our study of late middle age white and black participants did not find significant associations between lower levels of 25(OH)D with lower cognitive test scores at baseline, change in scores over time or dementia risk.

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