TY - JOUR
T1 - Vitamin D adsorption in healthy subjects and in patients with intestinal malabsorption syndromes
AU - Lo, C. W.
AU - Paris, P. W.
AU - Clemens, T. L.
PY - 1985
Y1 - 1985
N2 - We developed a test procedure for the clinical evaluation of the absorption of vitamin D. Serum vitamin D concentrations were evaluated in seven patients with intestinal fat malabsorption syndromes and in seven healthy, normal subjects, after being given a single oral dose of 50,000 IU (1.25 mg) vitamin D2. In the normal subjects, serum vitamin D concentrations rose from a baseline of less than 5 ng/ml to a peak over 50 ng/ml by 12 h, gradually falling to baseline levels by 3 days. In five of the seven patients with intestinal fat malabsorption, oral administration of 50,000 IU vitamin D2 did not raise serum vitamin D concentrations above 10 ng/ml. Two patients with severe inflammatory bowel disease had a normal absorption pattern, however. These findings suggest that an oral vitamin D absorption test may be of value for determination of patients at risk for development of vitamin D deficiency. Thay also raise questions about the efficacy of oral vitamin D preparations in patients with intestial fat malabsorption.
AB - We developed a test procedure for the clinical evaluation of the absorption of vitamin D. Serum vitamin D concentrations were evaluated in seven patients with intestinal fat malabsorption syndromes and in seven healthy, normal subjects, after being given a single oral dose of 50,000 IU (1.25 mg) vitamin D2. In the normal subjects, serum vitamin D concentrations rose from a baseline of less than 5 ng/ml to a peak over 50 ng/ml by 12 h, gradually falling to baseline levels by 3 days. In five of the seven patients with intestinal fat malabsorption, oral administration of 50,000 IU vitamin D2 did not raise serum vitamin D concentrations above 10 ng/ml. Two patients with severe inflammatory bowel disease had a normal absorption pattern, however. These findings suggest that an oral vitamin D absorption test may be of value for determination of patients at risk for development of vitamin D deficiency. Thay also raise questions about the efficacy of oral vitamin D preparations in patients with intestial fat malabsorption.
UR - http://www.scopus.com/inward/record.url?scp=0021891951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021891951&partnerID=8YFLogxK
U2 - 10.1093/ajcn/42.4.644
DO - 10.1093/ajcn/42.4.644
M3 - Article
C2 - 4050723
AN - SCOPUS:0021891951
SN - 0002-9165
VL - 42
SP - 644
EP - 649
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 4
ER -