Abstract
Vitamin D receptors are expressed on a wide variety of tissues, including immune cells. Polymorphisms of their genes have been linked to a number of diseases, including IBD and colorectal cancer. Vitamin D insufficiency has been reported to occur in up to 75% of individuals with Crohn's disease and 35% of patients with ulcerative colitis. Vitamin D counteracts Th1 responses, which drive proinflammatory pathways in IBD. Studies have shown a consistent link between the presence of vitamin D and either improved parameters or delayed development of colitis.
Original language | English (US) |
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Pages (from-to) | 738-740 |
Number of pages | 3 |
Journal | Nutrition in Clinical Practice |
Volume | 24 |
Issue number | 6 |
DOIs | |
State | Published - 2009 |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics