Vitamin D receptors are expressed on a wide variety of tissues, including immune cells. Polymorphisms of their genes have been linked to a number of diseases, including IBD and colorectal cancer. Vitamin D insufficiency has been reported to occur in up to 75% of individuals with Crohn's disease and 35% of patients with ulcerative colitis. Vitamin D counteracts Th1 responses, which drive proinflammatory pathways in IBD. Studies have shown a consistent link between the presence of vitamin D and either improved parameters or delayed development of colitis.
|Original language||English (US)|
|Number of pages||3|
|Journal||Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition|
|Publication status||Published - 2009|
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics