Vitamin B(12) deficiency with bilateral globus pallidus abnormalities.

Anjail Z. Sharrief, Joel Raffel, David S. Zee

Research output: Contribution to journalArticle


To describe a case of vitamin B(12) deficiency with classic and rare clinical features and novel radiographic features. Case report. Johns Hopkins Hospital neurology service. Middle-aged man with neuropathy, myelopathy,impaired cognition, and extrapyramidal signs. The patient had neurologic and hematologic signs of vitamin B(12) deficiency, with elevated methylmalonic acid and homocysteine levels. Brain magnetic resonance imaging showed signal abnormality in the globi pallidi, as can be seen in inherited methylmalonic acidemia.The clinical and radiographic findings reversed with vitamin B(12) administration. Vitamin B(12) deficiency can present with extrapyramidal symptoms and reversible bilateral globus pallidus abnormalities.

Original languageEnglish (US)
Pages (from-to)769-772
Number of pages4
JournalArchives of neurology
Issue number6
StatePublished - Jun 2012
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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