Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs

Kira Leishear, Luigi Ferrucci, Fulvio Lauretani, Robert M. Boudreau, Stephanie A. Studenski, Caterina Rosano, Rosanna Abbate, Anna M. Gori, Anna M. Corsi, Angelo Di Iorio, Jack M. Guralnik, Stefania Bandinelli, Anne B. Newman, Elsa S. Strotmeyer

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Low vitamin B12 and high homocysteine (Hcy) levels are common in older adults and may be associated with worse neurological function. The aim of this study is to determine whether changes in B12 or Hcy levels are associated with longitudinal changes in peripheral nerve function and clinical neurological signs and symptoms. Methods: Participants aged 60 years and older at baseline (n = 678; 72.2 ± 6.2 years; 43.5% male) were from the InCHIANTI Study. Low B12 (

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67 A
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

Keywords

  • Homocysteine
  • Neurological signs
  • Peripheral nerve function
  • Vitamin B12

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs'. Together they form a unique fingerprint.

Cite this