Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs

Kira Leishear; Luigi Ferrucci; Fulvio Lauretani; Robert M. Boudreau; Stephanie A. Studenski; Caterina Rosano; Rosanna Abbate; Anna M. Gori; Anna M. Corsi; Angelo Di Iorio; Jack M. Guralnik; Stefania Bandinelli; Anne B. Newman; Elsa S. Strotmeyer

doi:10.1093/gerona/glr202

Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs

Kira Leishear, Luigi Ferrucci, Fulvio Lauretani, Robert M. Boudreau, Stephanie A. Studenski, Caterina Rosano, Rosanna Abbate, Anna M. Gori, Anna M. Corsi, Angelo Di Iorio, Jack M. Guralnik, Stefania Bandinelli, Anne B. Newman, Elsa S. Strotmeyer

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Background: Low vitamin B12 and high homocysteine (Hcy) levels are common in older adults and may be associated with worse neurological function. The aim of this study is to determine whether changes in B12 or Hcy levels are associated with longitudinal changes in peripheral nerve function and clinical neurological signs and symptoms. Methods: Participants aged 60 years and older at baseline (n = 678; 72.2 ± 6.2 years; 43.5% male) were from the InCHIANTI Study. Low B12 (

Original language	English (US)
Pages (from-to)	537-543
Number of pages	7
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	67 A
Issue number	5
DOIs	https://doi.org/10.1093/gerona/glr202
State	Published - May 2012
Externally published	Yes

Keywords

Homocysteine
Neurological signs
Peripheral nerve function
Vitamin B12

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology
General Medicine

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10.1093/gerona/glr202

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Leishear, K., Ferrucci, L., Lauretani, F., Boudreau, R. M., Studenski, S. A., Rosano, C., Abbate, R., Gori, A. M., Corsi, A. M., Di Iorio, A., Guralnik, J. M., Bandinelli, S., Newman, A. B., & Strotmeyer, E. S. (2012). Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 67 A(5), 537-543. https://doi.org/10.1093/gerona/glr202

Leishear, K, Ferrucci, L, Lauretani, F, Boudreau, RM, Studenski, SA, Rosano, C, Abbate, R, Gori, AM, Corsi, AM, Di Iorio, A, Guralnik, JM, Bandinelli, S, Newman, AB & Strotmeyer, ES 2012, 'Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 67 A, no. 5, pp. 537-543. https://doi.org/10.1093/gerona/glr202

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abstract = "Background: Low vitamin B12 and high homocysteine (Hcy) levels are common in older adults and may be associated with worse neurological function. The aim of this study is to determine whether changes in B12 or Hcy levels are associated with longitudinal changes in peripheral nerve function and clinical neurological signs and symptoms. Methods: Participants aged 60 years and older at baseline (n = 678; 72.2 ± 6.2 years; 43.5% male) were from the InCHIANTI Study. Low B12 (",

keywords = "Homocysteine, Neurological signs, Peripheral nerve function, Vitamin B12",

author = "Kira Leishear and Luigi Ferrucci and Fulvio Lauretani and Boudreau, {Robert M.} and Studenski, {Stephanie A.} and Caterina Rosano and Rosanna Abbate and Gori, {Anna M.} and Corsi, {Anna M.} and {Di Iorio}, Angelo and Guralnik, {Jack M.} and Stefania Bandinelli and Newman, {Anne B.} and Strotmeyer, {Elsa S.}",

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doi = "10.1093/gerona/glr202",

language = "English (US)",

volume = "67 A",

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AU - Leishear, Kira

AU - Ferrucci, Luigi

AU - Lauretani, Fulvio

AU - Boudreau, Robert M.

AU - Studenski, Stephanie A.

AU - Rosano, Caterina

AU - Abbate, Rosanna

AU - Gori, Anna M.

AU - Corsi, Anna M.

AU - Di Iorio, Angelo

AU - Guralnik, Jack M.

AU - Bandinelli, Stefania

AU - Newman, Anne B.

AU - Strotmeyer, Elsa S.

PY - 2012/5

Y1 - 2012/5

N2 - Background: Low vitamin B12 and high homocysteine (Hcy) levels are common in older adults and may be associated with worse neurological function. The aim of this study is to determine whether changes in B12 or Hcy levels are associated with longitudinal changes in peripheral nerve function and clinical neurological signs and symptoms. Methods: Participants aged 60 years and older at baseline (n = 678; 72.2 ± 6.2 years; 43.5% male) were from the InCHIANTI Study. Low B12 (

AB - Background: Low vitamin B12 and high homocysteine (Hcy) levels are common in older adults and may be associated with worse neurological function. The aim of this study is to determine whether changes in B12 or Hcy levels are associated with longitudinal changes in peripheral nerve function and clinical neurological signs and symptoms. Methods: Participants aged 60 years and older at baseline (n = 678; 72.2 ± 6.2 years; 43.5% male) were from the InCHIANTI Study. Low B12 (

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Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs

Abstract

Keywords

ASJC Scopus subject areas

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