TY - JOUR
T1 - Vitamin A intervention
T2 - Short-term effects of a single, oral, massive dose on iron metabolism
AU - Bloem, Martin W.
AU - Wedel, Michel
AU - Van Agtmaal, Eric J.
AU - Speek, Andries J.
AU - Saowakontha, Sastri
AU - Schreurs, Wil H.P.
PY - 1990/1
Y1 - 1990/1
N2 - A group of 134 school children aged 3-9 y, with signs of conjunctival xerosis, from the rural area of the Sakorn Nakhon province in Northeast Thailand were selected for a controlled study on the short-term effect (2 wk) of a single, oral high dose of vitamin A on iron metabolism. After collection of the baseline data, children within villages were randomly assigned to receive the capsules (n = 65) or serve as control subjects (n = 69). Two weeks after supplementation significant increases of retinol, retinol-binding protein, hemoglobin, hematocrit, serum iron, and saturation of transferrin were found in the supplemented group. Ferritin concentrations did not change significantly. These short-term changes completely exclude seasonal effects and change in morbidity. This study provides further evidence of a causal association between vitamin A and iron metabolism. In areas where vitamin A deficiency is endemic, periodic massive vitamin A dose programs can also improve iron status of the population.
AB - A group of 134 school children aged 3-9 y, with signs of conjunctival xerosis, from the rural area of the Sakorn Nakhon province in Northeast Thailand were selected for a controlled study on the short-term effect (2 wk) of a single, oral high dose of vitamin A on iron metabolism. After collection of the baseline data, children within villages were randomly assigned to receive the capsules (n = 65) or serve as control subjects (n = 69). Two weeks after supplementation significant increases of retinol, retinol-binding protein, hemoglobin, hematocrit, serum iron, and saturation of transferrin were found in the supplemented group. Ferritin concentrations did not change significantly. These short-term changes completely exclude seasonal effects and change in morbidity. This study provides further evidence of a causal association between vitamin A and iron metabolism. In areas where vitamin A deficiency is endemic, periodic massive vitamin A dose programs can also improve iron status of the population.
KW - Iron
KW - Northeast Thailand
KW - Vitamin A
KW - Vitamin A supplementation
KW - Vitamin A-iron interaction
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U2 - 10.1093/ajcn/51.1.76
DO - 10.1093/ajcn/51.1.76
M3 - Article
C2 - 2296931
AN - SCOPUS:0025021696
SN - 0002-9165
VL - 51
SP - 76
EP - 79
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 1
ER -