Vitamin a deficiency and T-cell subpopulations in children with meningococcal disease

R. D. Semba, M. Bulterys, V. Munyeshuli, T. Gatsinzi, A. Saah, A. Chao, A. Dushimimana

Research output: Contribution to journalArticle

Abstract

Although group A meningococcal disease is a major cause of child morbidity and mortality in sub-Saharan Africa, little is known about vitamin A status and T-cell subpopulations in affected children. A prospective study of vitamin A levels and T-cell subpopulations was conducted in 41 children hospitalized for meningococcal meningitis in Butare, Rwanda, during an epidemic from September through November, 1992. The mean age of cases was 3.6 ± 2.7 years (range 0.5-16 years). The case-fatality rate was 20 per cent; 73 per cent of the children had serum vitamin A levels consistent with subclinical deficiency (< 0.7 μmol/l), and 27 per cent had levels consistent with severe deficiency (< 0.35 μmol/l). Mean CD4 per cent was higher and CD8 per cent was lower among children with meningitis compared with known reference populations. These results suggest that meningococcal disease is characterized by T-cell subpopulation alterations and vitamin A deficiency.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalJournal of tropical pediatrics
Volume42
Issue number5
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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    Semba, R. D., Bulterys, M., Munyeshuli, V., Gatsinzi, T., Saah, A., Chao, A., & Dushimimana, A. (1996). Vitamin a deficiency and T-cell subpopulations in children with meningococcal disease. Journal of tropical pediatrics, 42(5), 287-290. https://doi.org/10.1093/tropej/42.5.287