Vitamin A deficiency and increased mortality among human immunodeficiency virus-infected adults in Uganda

Peter Langi, Richard D. Semba, Roy D. Mugerwa, Christopher C. Whalen

Research output: Contribution to journalArticlepeer-review

Abstract

The specific aims of the study were to determine the prevalence of vitamin A deficiency and to examine the relationship between vitamin A deficiency and mortality among human immunodeficiency virus (HIV)-infected adults in sub-Saharan Africa. A prospective cohort study was conducted at the outpatient clinic of Mulago Hospital, Kampala, Uganda, among HIV-infected adults enrolled in the placebo arms of a randomized clinical trial to prevent Mycobacterium tuberculosis infection. Of 519 subjects at enrollment, 186 (36%) had serum vitamin A concentrations consistent with deficiency (<1.05 μmol/L). During follow-up (median 17 months), the mortality among subjects with and without vitamin A deficiency at enrollment was 30% and 17%, respectively (P = 0.01). In a multivariate model adjusting for CD4+ lymphocyte count, age, sex, anergy status, body mass index, and diarrhea, vitamin A deficiency was associated with a significantly elevated risk of death [relative risk (RR) = 1.78, 95% confidence interval (CI) 1.2-2.6]. Vitamin A deficiency is common among HIV-infected adults in this sub-Saharan population and is associated with higher mortality.

Original languageEnglish (US)
Pages (from-to)595-605
Number of pages11
JournalNutrition Research
Volume23
Issue number5
DOIs
StatePublished - May 1 2003

Keywords

  • Acquired immmunodeficiency syndrome
  • Human immunodeficiency virus
  • Mortality
  • Retinol
  • Uganda
  • Vitamin A

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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