Vitamin a contents of rat intestinal epithelium and jejunal mucinous adenocarcinoma

P. Ramnathan Sundaresan, Luigi M. De Luca

Research output: Contribution to journalArticle

Abstract

Concentrations of retinol and retinyl esters were assayed in rat intestinal mucosa and in chemically induced transplanted mucinous adenocarcinoma of the jejunum. Lipid extract from the tissues was chromatographed on deactivated alumina to isolate retinol and retinyl esters, which were determined by specific spectrofluorometry. Normal intestinal mucosa tissue contains 556 ng of retinol equivalents as retinyl esters and 303 ng of free retinol/g of wet tissue. The concentration of retinyl esters in the intestinal mucosa from rats carrying the transplanted tumor was 341 ng/g wet tissue; no free retinol was detected in the small intestinal epithelium of these rats. Liver tissue from the tumorbearing rats contained 157 μg of retinol equivalents as retinyl esters and 136 μg of free retinol/g of wet tissue. The concentration of vitamin A per cell in the adenocarcinoma tissue was about 20 times less than that in intestinal epithelium.

Original languageEnglish (US)
Pages (from-to)1643-1645
Number of pages3
JournalJournal of the National Cancer Institute
Volume58
Issue number6
DOIs
StatePublished - Jun 1977
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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