Vitamin A and zinc therapy in primary biliary cirrhosis

H. F. Herlong, R. M. Russell, W. C. Maddrey

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Eleven patients with primary biliary cirrhosis were surveyed for evidence of vitamin A and zinc deficiencies. Vitamin A deficiency manifested as a low serum vitamin A concentration and abnormal dark adaptation was present in 9 of the 11 patients. A low serum zinc level was present in four patients who were also vitamin A deficient. All seven patients who received p.o. vitamin A therapy with 25,000 to 50,000 units per day for 4 to 12 weeks achieved normal vitamin A levels. Normalization of serum vitamin A was associated with significant improvement in dark adaptation (p

Original languageEnglish (US)
Pages (from-to)348-351
Number of pages4
Issue number4
StatePublished - 1981

ASJC Scopus subject areas

  • Hepatology


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