TY - JOUR
T1 - Vitamin A and immunity to viral, bacterial and protozoan infections
AU - Semba, R. D.
N1 - Funding Information:
This work was supported in part by the National Institute of Health (HD30042, HD32247, AI41956), the Fogarty International Center and the United States Agency for International Development (Cooperative Agreement HRN-A-00–97–00015–00).
PY - 1999/8
Y1 - 1999/8
N2 - Studies in animal models and cell lines show that vitamin A and related retinoids play a major role in immunity, including expression of mucins and keratins, lymphopoiesis, apoptosis, cytokine expression, production of antibody, and the function of neutrophils, natural killer cells, monocytes or macrophages, T lymphocytes and B lymphocytes. Recent clinical trials suggest that vitamin A supplementation reduces morbidity and mortality in different infectious diseases, such as measles, diarrhoeal disease, measles-related pneumonia, human immunodeficiency virus infection and malaria. Immune responses vary considerably during different infections, and the available data suggest that the modulation of immune function by vitamin A may also vary widely, depending on the type of infection and immune responses involved.
AB - Studies in animal models and cell lines show that vitamin A and related retinoids play a major role in immunity, including expression of mucins and keratins, lymphopoiesis, apoptosis, cytokine expression, production of antibody, and the function of neutrophils, natural killer cells, monocytes or macrophages, T lymphocytes and B lymphocytes. Recent clinical trials suggest that vitamin A supplementation reduces morbidity and mortality in different infectious diseases, such as measles, diarrhoeal disease, measles-related pneumonia, human immunodeficiency virus infection and malaria. Immune responses vary considerably during different infections, and the available data suggest that the modulation of immune function by vitamin A may also vary widely, depending on the type of infection and immune responses involved.
KW - Immunity
KW - Infection
KW - Malaria
KW - Measles
KW - Vitamin A
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U2 - 10.1017/S0029665199000944
DO - 10.1017/S0029665199000944
M3 - Article
C2 - 10604208
AN - SCOPUS:0032756346
SN - 0029-6651
VL - 58
SP - 719
EP - 727
JO - Proceedings of the Nutrition Society
JF - Proceedings of the Nutrition Society
IS - 3
ER -