The fundamental observation (reviewed in Ref. 40) that vitamin A deficiency leads to a profound change in the differentiation of epithelial tissues has led investigators to suggest and eventually prove that the action of the vitamin is similar to that of steroid hormones, i.e., that retinoic acid activates gene expression through nuclear receptors in a variety of tissues. It should be noted that this concept has also included mesenchymal tissues and, in fact, the most well-known clinical application of retinoic acid is in differentiation therapy of acute promyelocytic leukemic cells to mature granulocytes.
|Original language||English (US)|
|Title of host publication||Nutrient-Gene Interactions in Health and Disease|
|Number of pages||37|
|ISBN (Print)||0849322162, 9780849322167|
|State||Published - Jan 1 2001|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)