Vitamin A and gene expression

Peter McCaffery, Fausto Andreola, Valeria Giandomenico, Luigi M. De Luca

Research output: Chapter in Book/Report/Conference proceedingChapter


The fundamental observation (reviewed in Ref. 40) that vitamin A deficiency leads to a profound change in the differentiation of epithelial tissues has led investigators to suggest and eventually prove that the action of the vitamin is similar to that of steroid hormones, i.e., that retinoic acid activates gene expression through nuclear receptors in a variety of tissues. It should be noted that this concept has also included mesenchymal tissues and, in fact, the most well-known clinical application of retinoic acid is in differentiation therapy of acute promyelocytic leukemic cells to mature granulocytes.

Original languageEnglish (US)
Title of host publicationNutrient-Gene Interactions in Health and Disease
PublisherCRC Press
Number of pages37
ISBN (Electronic)9781420039108
ISBN (Print)0849322162, 9780849322167
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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