TY - JOUR
T1 - Visually cued action timing in the primary visual cortex
AU - Namboodiri, Vijay Mohan K.
AU - Huertas, Marco A.
AU - Monk, Kevin J.
AU - Shouval, Harel Z.
AU - Shuler, Marshall G.Hussain
N1 - Funding Information:
The authors thank Stefan Mihalas, Joshua Levy, Tanya Marton, Emma Roach, and Camila Zold for helpful discussions throughout the work, and Simon Allard for comments on the manuscript. This work was funded by NIMH (R01 MH084911 and R01 MH093665) to M.G.H.S. The microscope used for visualizing histology was funded by NINDS (NS050274).
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/4/8
Y1 - 2015/4/8
N2 - Most behaviors are generated in three steps: sensing the external world, processing that information toinstruct decision-making, and producing a motor action. Sensory areas, especially primary sensory cortices, have long been held to be involved only in the first step of this sequence. Here, we develop a visually cued interval timing task that requires rats to decide when to perform an action following a brief visual stimulus. Using single-unit recordings and optogenetics in this task, we show that activity generated by the primary visual cortex (V1) embodies the target interval and may instruct the decision to time the action on a trial-by-trial basis. A spiking neuronal model of local recurrent connections in V1 produces neural responses that predict and drive the timing offuture actions, rationalizing our observations. Our data demonstrate that the primary visual cortex may contribute to the instruction of visually cued timed actions.
AB - Most behaviors are generated in three steps: sensing the external world, processing that information toinstruct decision-making, and producing a motor action. Sensory areas, especially primary sensory cortices, have long been held to be involved only in the first step of this sequence. Here, we develop a visually cued interval timing task that requires rats to decide when to perform an action following a brief visual stimulus. Using single-unit recordings and optogenetics in this task, we show that activity generated by the primary visual cortex (V1) embodies the target interval and may instruct the decision to time the action on a trial-by-trial basis. A spiking neuronal model of local recurrent connections in V1 produces neural responses that predict and drive the timing offuture actions, rationalizing our observations. Our data demonstrate that the primary visual cortex may contribute to the instruction of visually cued timed actions.
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U2 - 10.1016/j.neuron.2015.02.043
DO - 10.1016/j.neuron.2015.02.043
M3 - Article
C2 - 25819611
AN - SCOPUS:84930382836
SN - 0896-6273
VL - 86
SP - 319
EP - 330
JO - Neuron
JF - Neuron
IS - 1
ER -