TY - JOUR
T1 - Visualizing the dynamics of tuberculosis pathology using molecular imaging
AU - Ordonez, Alvaro A.
AU - Tucker, Elizabeth W.
AU - Anderson, Carolyn J.
AU - Carter, Claire L.
AU - Ganatra, Shashank
AU - Kaushal, Deepak
AU - Kramnik, Igor
AU - Lin, Philana L.
AU - Madigan, Cressida A.
AU - Mendez, Susana
AU - Rao, Jianghong
AU - Savic, Rada M.
AU - Tobin, David M.
AU - Walzl, Gerhard
AU - Wilkinson, Robert J.
AU - Lacourciere, Karen A.
AU - Via, Laura E.
AU - Jain, Sanjay K.
N1 - Funding Information:
This Review was inspired by a workshop sponsored by the US National Institute of Allergy and Infectious Diseases on August 26-27, 2019, supported by the Division of Microbiology and Infectious Diseases. We thank all the organizers, speakers, and participants. Logistical support from Mediso USA is also acknowledged. The views expressed in this article are solely those of the authors and do not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2021, Ordonez et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.
AB - Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.
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U2 - 10.1172/JCI145107
DO - 10.1172/JCI145107
M3 - Review article
C2 - 33645551
AN - SCOPUS:85102103538
VL - 131
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 5
M1 - e145107
ER -