Visualization of dopamine nerve terminals by positron tomography using [18F]fluoro-β-fluomethylene-m-tyrosine

O. T. DeJesus, J. E. Holden, C. Endres, D. Murali, T. R. Oakes, S. Shelton, Hideo Uno, D. Houser, L. Freund, S. B. Perlman, R. J. Nickles

Research output: Contribution to journalArticlepeer-review

Abstract

[18F]-6-Fluoro-β-fluoromethylene-m-tyrosine ([18F]FFMMT) was evaluated as a potential imaging agent for dopamine nerve terminals using positron emission tomography (PET). Biodistribution and time course of this tracer in mice after i.p. injection was consistent with the distribution of dopamine. PET imaging studies involving rhesus macaques showed specific uptake in the dopamine-rich caudate-putamen region. This specific localization was blocked by inhibiting the enzyme l-aromatic amino acid decarboxylase and the transport of the tracer into brain was shown to be stereospecific. These results show the promise of l-[18F]FFMMT as a PET tracer in monitoring degeneration of the CNS dopamine system.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalBrain research
Volume597
Issue number1
DOIs
StatePublished - Nov 27 1992

Keywords

  • Dopamine nerve terminal
  • MDL 72394
  • Parkinson's disease
  • Positron emission tomography
  • [F]Fluoro-β-fluoromethylene-m-tyrosine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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