Visual transduction in Drosophila

C. Montell

Research output: Contribution to journalArticle

Abstract

The Drosophila phototransduction cascade has emerged as an attractive paradigm for understanding the molecular mechanisms underlying visual transduction, as well as other G protein-coupled signaling cascades that are activated and terminated with great rapidity. A large collection of mutants affecting the fly visual cascade have been isolated, and the nature and function of many of the affected gene products have been identified. Virtually all of the proteins, including those that were initially classified as novel, are highly related to vertebrate homologs. Recently, it has become apparent that most of the proteins central to Drosophila phototransduction are coupled into a supramolecular signaling complex, signalplex, through association with a PDZ-containing scaffold protein. The characterization of this complex has led to a re-evaluation of the mechanisms underlying the activation and deactivation of the phototransduction cascade.

Original languageEnglish (US)
Pages (from-to)231-268
Number of pages38
JournalAnnual Review of Cell and Developmental Biology
Volume15
DOIs
StatePublished - 1999

Keywords

  • Calcium
  • G protein
  • Phototransduction
  • Signal transduction
  • Vision

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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