TY - JOUR
T1 - Visual Acuity Outcome over Time in Non-Infectious Uveitis
AU - Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group
AU - Pistilli, Maxwell
AU - Joffe, Marshall M.
AU - Gangaputra, Sapna S.
AU - Pujari, Siddharth S.
AU - Jabs, Douglas A.
AU - Levy-Clarke, Grace A.
AU - Nussenblatt, Robert B.
AU - Rosenbaum, James T.
AU - Sen, H. Nida
AU - Suhler, Eric B.
AU - Thorne, Jennifer E.
AU - Bhatt, Nirali P.
AU - Foster, C. Stephen
AU - Begum, Hosne
AU - Fitzgerald, Tonetta D.
AU - Dreger, Kurt A.
AU - Altaweel, Michael M.
AU - Holbrook, Janet T.
AU - Kempen, John H.
N1 - Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Introduction: We evaluated visual acuity (VA) over 5 years in a subspecialty noninfectious uveitis population. Methods: Retrospective data from 5,530 noninfectious uveitis patients with anterior, intermediate, posterior or panuveitis were abstracted by expert reviewers. Mean VA was calculated using inverse probability of censoring weighting to account for losses to follow-up. Results: Patients were a median of 41 years old, 65% female, and 73% white. Initial mean VA was worse among panuveitis (20/84) than posterior (20/64), intermediate (20/47), and anterior (20/37) uveitides. On average, mean VA improved by 0.62, 0.51, 0.37, and 0.26 logMAR-equivalent lines over 2 years, respectively (each P <.001), then remained stable, except posterior uveitis mean VA worsened to initial levels. Conclusion: Mean VA of uveitic eyes improved and, typically, improvement was sustained under uveitis subspecialty care. Because VA tends to improve under tertiary care, mean VA change appears a better outcome for clinical studies than time-to-loss of VA.
AB - Introduction: We evaluated visual acuity (VA) over 5 years in a subspecialty noninfectious uveitis population. Methods: Retrospective data from 5,530 noninfectious uveitis patients with anterior, intermediate, posterior or panuveitis were abstracted by expert reviewers. Mean VA was calculated using inverse probability of censoring weighting to account for losses to follow-up. Results: Patients were a median of 41 years old, 65% female, and 73% white. Initial mean VA was worse among panuveitis (20/84) than posterior (20/64), intermediate (20/47), and anterior (20/37) uveitides. On average, mean VA improved by 0.62, 0.51, 0.37, and 0.26 logMAR-equivalent lines over 2 years, respectively (each P <.001), then remained stable, except posterior uveitis mean VA worsened to initial levels. Conclusion: Mean VA of uveitic eyes improved and, typically, improvement was sustained under uveitis subspecialty care. Because VA tends to improve under tertiary care, mean VA change appears a better outcome for clinical studies than time-to-loss of VA.
KW - Uveitis
KW - Visual acuity
KW - inverse probability of censoring weighting
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U2 - 10.1080/09273948.2019.1687733
DO - 10.1080/09273948.2019.1687733
M3 - Article
C2 - 31821051
AN - SCOPUS:85076423607
SN - 0927-3948
VL - 29
SP - 1064
EP - 1071
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 6
ER -