Visual acuity after cataract surgery in patients with age-related macular degeneration: Age-related eye disease study 2 report number 5

Nancy Huynh, Benjamin P. Nicholson, Elvira Agrón, Traci E. Clemons, Susan B. Bressler, Philip J. Rosenfeld, Emily Y. Chew

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Objective To evaluate visual acuity outcomes after cataract surgery in persons with varying degrees of severity of age-related macular degeneration (AMD). Design Cohort study. Participants A total of 1232 eyes of 793 participants who underwent cataract surgery during the Age-Related Eye Disease Study 2, a prospective, multicenter, randomized controlled trial of nutritional supplements for treatment of AMD. Methods Preoperative and postoperative characteristics of participants who underwent cataract extraction during the 5-year trial were analyzed. Both clinical data and standardized red-reflex lens and fundus photographs were obtained at baseline and annually. Photographs were graded by a centralized reading center for cortical and posterior subcapsular lens opacities and for AMD severity. Cataract surgery was documented at annual study visits or by history during the 6-month telephone calls. Analyses were conducted using multivariate repeated-measures regression. Main Outcome Measures Change in best-corrected visual acuity (BCVA) after cataract surgery compared with preoperative BCVA. Results Adjusting for age at time of surgery, gender, interval between preoperative and postoperative visits, and type and severity of cataract, the mean changes in visual acuity were as follows: eyes with mild AMD (n = 30) gained 11.2 letters (95% confidence interval [CI], 6.9-15.5), eyes with moderate AMD (n = 346) gained 11.1 letters (95% CI, 9.1-13.2), eyes with severe AMD (n = 462) gained 8.7 letters (95% CI, 6.7-10.7), eyes with noncentral geographic atrophy (n = 70) gained 8.9 letters (95% CI, 5.8-12.1), and eyes with advanced AMD (central geographic atrophy, neovascular disease, or both; n = 324) gained 6.8 letters (95% CI, 4.9-8.8). The visual acuity gain across all AMD severity groups was statistically significant from preoperative values (P < 0.0001). Conclusions Mean visual acuities improved significantly after cataract surgery across varying degrees of AMD severity.

Original languageEnglish (US)
Pages (from-to)1229-1236
Number of pages8
Issue number6
StatePublished - Jun 2014


  • AAS
  • AMD
  • AREDS AMD severity
  • AREDS2
  • Abbreviations and Acronyms
  • Age-Related Eye Disease Study
  • Age-Related Eye Disease Study 2
  • BCVA
  • CGA
  • CI
  • Early Treatment Diabetic Retinopathy Study
  • GA
  • PSC
  • VEGF
  • age-related macular degeneration
  • best-corrected visual acuity
  • central geographic atrophy
  • confidence interval
  • geographic atrophy
  • posterior subcapsular cataract
  • vascular endothelial growth factor

ASJC Scopus subject areas

  • Ophthalmology


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