Visna-maedi-like disease associated with an ovine retrovirus infection in a Corriedale sheep

W. D. Sheffield, O. Narayan, J. D. Strandberg, Robert John Adams

Research output: Contribution to journalArticle

Abstract

A visna-maedi-like disease was found in a Corriedale sheep from which a retrovirus sharing the group antigen of visna-progressive pneumonia virus was isolated from lung, brain, and spleen. Clinically, the sheep had acute neurologic signs and dyspnea. Pathologic examination showed lesions similar to both visna and maedi. In the lung, there was a patchy interstitial pneumonia with marked lymphoid hyperplasia. Changes in the central nervous system were necrotizing nonsuppurative encephalitis of the brain stem, poliomyelitis of the cervical cord, and ependymitis and subependymal gliosis of the ventricles. Histologically, the central nervous system lesions seemed to have arisen sequentially, perhaps in response to bursts of virus replication as the agent underwent possible antigenic mutation. The severe lesions in both the central nervous system and lungs suggested a virus strain with dual tropism.

Original languageEnglish (US)
Pages (from-to)544-552
Number of pages9
JournalVeterinary Pathology
Volume17
Issue number5
StatePublished - 1980

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Progressive Interstitial Pneumonia of Sheep
Retroviridae
Visna
Retroviridae Infections
Corriedale
lesions (animal)
central nervous system
Sheep
Central Nervous System
lungs
sheep
Lung
pneumonia
Subependymal Glioma
infection
Viruses
viruses
tropisms
Tropism
dyspnea

ASJC Scopus subject areas

  • veterinary(all)

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Visna-maedi-like disease associated with an ovine retrovirus infection in a Corriedale sheep. / Sheffield, W. D.; Narayan, O.; Strandberg, J. D.; Adams, Robert John.

In: Veterinary Pathology, Vol. 17, No. 5, 1980, p. 544-552.

Research output: Contribution to journalArticle

Sheffield, W. D. ; Narayan, O. ; Strandberg, J. D. ; Adams, Robert John. / Visna-maedi-like disease associated with an ovine retrovirus infection in a Corriedale sheep. In: Veterinary Pathology. 1980 ; Vol. 17, No. 5. pp. 544-552.
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