Visceral sensitivity to gastric stimulation and its correlation with alterations in gastric emptying and accommodation in humans

Shukun Yao, Meiyun Ke, Zhifeng Wang, Dabo Xu, Yanli Zhang, Jiande Chen

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to investigate the visceral sensation to gastric stimulation and its correlation with the stimulation-induced alterations in gastric accommodation and gastric emptying. Methods: The study was performed in 12 healthy human controls. Gastric stimulation was performed using bipolar electrodes attached to the mucosa of the distal stomach under endoscopy. Experiments were conducted on 3 consecutive days to investigate the effects of gastric stimulation with various parameters on visceral sensation, maximum intake of water and gastric emptying of solids. Results: 1) The stimulation energy was 265.6 ± 134.9 smA2 for the first sensation and 2,020.0 ± 865.1 smA2 for the maximum tolerance, and there was a large variation among the subjects; 2) Gastric stimulation with stimulation energy less than 50% of that required to induce the first sensation significantly reduced the maximum intake of water and delayed gastric emptying of solids without inducing symptoms; 3) The stimulation energy of the first sensation was significantly correlated with the stimulation-induced reduction in water intake (r=-0.80, P=0.02) and the stimulation-induced prolongation of gastric emptying (r=-0.78, P=0.003). That is, the inhibitory effects of gastric stimulation were more obvious in those subjects who were viscerally more sensitive to gastric stimulation. Conclusions: Gastric stimulation via the distal stomach reduces gastric accommodation and delays gastric emptying. These inhibitory effects are correlated with the visceral sensitivity of the individual to gastric stimulation. It is worthy to further investigate whether the outcome of the implantable gastric stimulation (IGS) therapy for obesity may be predicted from the visceral sensitivity of the patient to temporary gastric stimulation using endoscopically placed mucosal electrodes.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalObesity Surgery
Volume15
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

Gastric Emptying
Stomach
Drinking
Electrodes
Hypesthesia
Endoscopy
Mucous Membrane

Keywords

  • Food intake
  • Gastric accommodation
  • Gastric emptying
  • Gastric stimulation
  • Implantable gastric stimulation
  • Obesity

ASJC Scopus subject areas

  • Surgery

Cite this

Visceral sensitivity to gastric stimulation and its correlation with alterations in gastric emptying and accommodation in humans. / Yao, Shukun; Ke, Meiyun; Wang, Zhifeng; Xu, Dabo; Zhang, Yanli; Chen, Jiande.

In: Obesity Surgery, Vol. 15, No. 2, 02.2005, p. 247-253.

Research output: Contribution to journalArticle

Yao, Shukun ; Ke, Meiyun ; Wang, Zhifeng ; Xu, Dabo ; Zhang, Yanli ; Chen, Jiande. / Visceral sensitivity to gastric stimulation and its correlation with alterations in gastric emptying and accommodation in humans. In: Obesity Surgery. 2005 ; Vol. 15, No. 2. pp. 247-253.
@article{c8e8fc9d405148b7836d687be2372b52,
title = "Visceral sensitivity to gastric stimulation and its correlation with alterations in gastric emptying and accommodation in humans",
abstract = "Background: The aim of this study was to investigate the visceral sensation to gastric stimulation and its correlation with the stimulation-induced alterations in gastric accommodation and gastric emptying. Methods: The study was performed in 12 healthy human controls. Gastric stimulation was performed using bipolar electrodes attached to the mucosa of the distal stomach under endoscopy. Experiments were conducted on 3 consecutive days to investigate the effects of gastric stimulation with various parameters on visceral sensation, maximum intake of water and gastric emptying of solids. Results: 1) The stimulation energy was 265.6 ± 134.9 smA2 for the first sensation and 2,020.0 ± 865.1 smA2 for the maximum tolerance, and there was a large variation among the subjects; 2) Gastric stimulation with stimulation energy less than 50{\%} of that required to induce the first sensation significantly reduced the maximum intake of water and delayed gastric emptying of solids without inducing symptoms; 3) The stimulation energy of the first sensation was significantly correlated with the stimulation-induced reduction in water intake (r=-0.80, P=0.02) and the stimulation-induced prolongation of gastric emptying (r=-0.78, P=0.003). That is, the inhibitory effects of gastric stimulation were more obvious in those subjects who were viscerally more sensitive to gastric stimulation. Conclusions: Gastric stimulation via the distal stomach reduces gastric accommodation and delays gastric emptying. These inhibitory effects are correlated with the visceral sensitivity of the individual to gastric stimulation. It is worthy to further investigate whether the outcome of the implantable gastric stimulation (IGS) therapy for obesity may be predicted from the visceral sensitivity of the patient to temporary gastric stimulation using endoscopically placed mucosal electrodes.",
keywords = "Food intake, Gastric accommodation, Gastric emptying, Gastric stimulation, Implantable gastric stimulation, Obesity",
author = "Shukun Yao and Meiyun Ke and Zhifeng Wang and Dabo Xu and Yanli Zhang and Jiande Chen",
year = "2005",
month = "2",
doi = "10.1381/0960892053268363",
language = "English (US)",
volume = "15",
pages = "247--253",
journal = "Obesity Surgery",
issn = "0960-8923",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Visceral sensitivity to gastric stimulation and its correlation with alterations in gastric emptying and accommodation in humans

AU - Yao, Shukun

AU - Ke, Meiyun

AU - Wang, Zhifeng

AU - Xu, Dabo

AU - Zhang, Yanli

AU - Chen, Jiande

PY - 2005/2

Y1 - 2005/2

N2 - Background: The aim of this study was to investigate the visceral sensation to gastric stimulation and its correlation with the stimulation-induced alterations in gastric accommodation and gastric emptying. Methods: The study was performed in 12 healthy human controls. Gastric stimulation was performed using bipolar electrodes attached to the mucosa of the distal stomach under endoscopy. Experiments were conducted on 3 consecutive days to investigate the effects of gastric stimulation with various parameters on visceral sensation, maximum intake of water and gastric emptying of solids. Results: 1) The stimulation energy was 265.6 ± 134.9 smA2 for the first sensation and 2,020.0 ± 865.1 smA2 for the maximum tolerance, and there was a large variation among the subjects; 2) Gastric stimulation with stimulation energy less than 50% of that required to induce the first sensation significantly reduced the maximum intake of water and delayed gastric emptying of solids without inducing symptoms; 3) The stimulation energy of the first sensation was significantly correlated with the stimulation-induced reduction in water intake (r=-0.80, P=0.02) and the stimulation-induced prolongation of gastric emptying (r=-0.78, P=0.003). That is, the inhibitory effects of gastric stimulation were more obvious in those subjects who were viscerally more sensitive to gastric stimulation. Conclusions: Gastric stimulation via the distal stomach reduces gastric accommodation and delays gastric emptying. These inhibitory effects are correlated with the visceral sensitivity of the individual to gastric stimulation. It is worthy to further investigate whether the outcome of the implantable gastric stimulation (IGS) therapy for obesity may be predicted from the visceral sensitivity of the patient to temporary gastric stimulation using endoscopically placed mucosal electrodes.

AB - Background: The aim of this study was to investigate the visceral sensation to gastric stimulation and its correlation with the stimulation-induced alterations in gastric accommodation and gastric emptying. Methods: The study was performed in 12 healthy human controls. Gastric stimulation was performed using bipolar electrodes attached to the mucosa of the distal stomach under endoscopy. Experiments were conducted on 3 consecutive days to investigate the effects of gastric stimulation with various parameters on visceral sensation, maximum intake of water and gastric emptying of solids. Results: 1) The stimulation energy was 265.6 ± 134.9 smA2 for the first sensation and 2,020.0 ± 865.1 smA2 for the maximum tolerance, and there was a large variation among the subjects; 2) Gastric stimulation with stimulation energy less than 50% of that required to induce the first sensation significantly reduced the maximum intake of water and delayed gastric emptying of solids without inducing symptoms; 3) The stimulation energy of the first sensation was significantly correlated with the stimulation-induced reduction in water intake (r=-0.80, P=0.02) and the stimulation-induced prolongation of gastric emptying (r=-0.78, P=0.003). That is, the inhibitory effects of gastric stimulation were more obvious in those subjects who were viscerally more sensitive to gastric stimulation. Conclusions: Gastric stimulation via the distal stomach reduces gastric accommodation and delays gastric emptying. These inhibitory effects are correlated with the visceral sensitivity of the individual to gastric stimulation. It is worthy to further investigate whether the outcome of the implantable gastric stimulation (IGS) therapy for obesity may be predicted from the visceral sensitivity of the patient to temporary gastric stimulation using endoscopically placed mucosal electrodes.

KW - Food intake

KW - Gastric accommodation

KW - Gastric emptying

KW - Gastric stimulation

KW - Implantable gastric stimulation

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=14644433693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14644433693&partnerID=8YFLogxK

U2 - 10.1381/0960892053268363

DO - 10.1381/0960892053268363

M3 - Article

C2 - 15802069

AN - SCOPUS:14644433693

VL - 15

SP - 247

EP - 253

JO - Obesity Surgery

JF - Obesity Surgery

SN - 0960-8923

IS - 2

ER -