Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping

M. Kazui, K. A. Andreoni, G. M. Williams, Bruce Alan Perler, G. B. Bulkley, C. Beattie, R. T. Donham, S. S. Sehnert, James F. Burdick, Terence H Risby

Research output: Contribution to journalArticle

Abstract

Purpose: Recently, we have reported that lipid peroxidation specific to oxygen free radical-mediated injury increased immediately after reperfusion of human liver allografts. However, in the human liver transplantation setting it was impossible to disassociate the contributions to lipid peroxidation caused by the warm and cold ischemic phases from those caused by reperfusion. Therefore we now have studied lipid peroxidation at reperfusion after supraceliac aortic cross-clamping in patients with normal livers. Methods: Ethane, a noninvasive biomarker of lipid peroxidation, was measured in exhaled breath of patients before and during cross-clamping of the thoracic aorta and at sequential time intervals after visceral reperfusion. Results: Approximately a two-fold transient increase in the ethane level was observed at around 15 minutes after reperfusion in those patients whose aortas were cross-clamped for more than 18 minutes. Conclusions: These results indicate that free radical-mediated lipid peroxidation occurs at reperfusion of warm ischemic viscera in the clinical setting of aortic repair. This observation supports the hypothesis that substantial lipid peroxidation occurs when tissues are subjected to cold or warm ischemia followed by reperfusion.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalJournal of Vascular Surgery
Volume19
Issue number3
StatePublished - 1994

Fingerprint

Constriction
Lipid Peroxidation
Reperfusion
Ethane
Free Radicals
Cold Ischemia
Warm Ischemia
Viscera
Liver
Thoracic Aorta
Liver Transplantation
Allografts
Aorta
Reactive Oxygen Species
Biomarkers
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Kazui, M., Andreoni, K. A., Williams, G. M., Perler, B. A., Bulkley, G. B., Beattie, C., ... Risby, T. H. (1994). Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping. Journal of Vascular Surgery, 19(3), 473-477.

Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping. / Kazui, M.; Andreoni, K. A.; Williams, G. M.; Perler, Bruce Alan; Bulkley, G. B.; Beattie, C.; Donham, R. T.; Sehnert, S. S.; Burdick, James F.; Risby, Terence H.

In: Journal of Vascular Surgery, Vol. 19, No. 3, 1994, p. 473-477.

Research output: Contribution to journalArticle

Kazui, M, Andreoni, KA, Williams, GM, Perler, BA, Bulkley, GB, Beattie, C, Donham, RT, Sehnert, SS, Burdick, JF & Risby, TH 1994, 'Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping', Journal of Vascular Surgery, vol. 19, no. 3, pp. 473-477.
Kazui M, Andreoni KA, Williams GM, Perler BA, Bulkley GB, Beattie C et al. Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping. Journal of Vascular Surgery. 1994;19(3):473-477.
Kazui, M. ; Andreoni, K. A. ; Williams, G. M. ; Perler, Bruce Alan ; Bulkley, G. B. ; Beattie, C. ; Donham, R. T. ; Sehnert, S. S. ; Burdick, James F. ; Risby, Terence H. / Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping. In: Journal of Vascular Surgery. 1994 ; Vol. 19, No. 3. pp. 473-477.
@article{2e6b2658c910419eb05a6af6b0307c87,
title = "Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping",
abstract = "Purpose: Recently, we have reported that lipid peroxidation specific to oxygen free radical-mediated injury increased immediately after reperfusion of human liver allografts. However, in the human liver transplantation setting it was impossible to disassociate the contributions to lipid peroxidation caused by the warm and cold ischemic phases from those caused by reperfusion. Therefore we now have studied lipid peroxidation at reperfusion after supraceliac aortic cross-clamping in patients with normal livers. Methods: Ethane, a noninvasive biomarker of lipid peroxidation, was measured in exhaled breath of patients before and during cross-clamping of the thoracic aorta and at sequential time intervals after visceral reperfusion. Results: Approximately a two-fold transient increase in the ethane level was observed at around 15 minutes after reperfusion in those patients whose aortas were cross-clamped for more than 18 minutes. Conclusions: These results indicate that free radical-mediated lipid peroxidation occurs at reperfusion of warm ischemic viscera in the clinical setting of aortic repair. This observation supports the hypothesis that substantial lipid peroxidation occurs when tissues are subjected to cold or warm ischemia followed by reperfusion.",
author = "M. Kazui and Andreoni, {K. A.} and Williams, {G. M.} and Perler, {Bruce Alan} and Bulkley, {G. B.} and C. Beattie and Donham, {R. T.} and Sehnert, {S. S.} and Burdick, {James F.} and Risby, {Terence H}",
year = "1994",
language = "English (US)",
volume = "19",
pages = "473--477",
journal = "Journal of Vascular Surgery",
issn = "0741-5214",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping

AU - Kazui, M.

AU - Andreoni, K. A.

AU - Williams, G. M.

AU - Perler, Bruce Alan

AU - Bulkley, G. B.

AU - Beattie, C.

AU - Donham, R. T.

AU - Sehnert, S. S.

AU - Burdick, James F.

AU - Risby, Terence H

PY - 1994

Y1 - 1994

N2 - Purpose: Recently, we have reported that lipid peroxidation specific to oxygen free radical-mediated injury increased immediately after reperfusion of human liver allografts. However, in the human liver transplantation setting it was impossible to disassociate the contributions to lipid peroxidation caused by the warm and cold ischemic phases from those caused by reperfusion. Therefore we now have studied lipid peroxidation at reperfusion after supraceliac aortic cross-clamping in patients with normal livers. Methods: Ethane, a noninvasive biomarker of lipid peroxidation, was measured in exhaled breath of patients before and during cross-clamping of the thoracic aorta and at sequential time intervals after visceral reperfusion. Results: Approximately a two-fold transient increase in the ethane level was observed at around 15 minutes after reperfusion in those patients whose aortas were cross-clamped for more than 18 minutes. Conclusions: These results indicate that free radical-mediated lipid peroxidation occurs at reperfusion of warm ischemic viscera in the clinical setting of aortic repair. This observation supports the hypothesis that substantial lipid peroxidation occurs when tissues are subjected to cold or warm ischemia followed by reperfusion.

AB - Purpose: Recently, we have reported that lipid peroxidation specific to oxygen free radical-mediated injury increased immediately after reperfusion of human liver allografts. However, in the human liver transplantation setting it was impossible to disassociate the contributions to lipid peroxidation caused by the warm and cold ischemic phases from those caused by reperfusion. Therefore we now have studied lipid peroxidation at reperfusion after supraceliac aortic cross-clamping in patients with normal livers. Methods: Ethane, a noninvasive biomarker of lipid peroxidation, was measured in exhaled breath of patients before and during cross-clamping of the thoracic aorta and at sequential time intervals after visceral reperfusion. Results: Approximately a two-fold transient increase in the ethane level was observed at around 15 minutes after reperfusion in those patients whose aortas were cross-clamped for more than 18 minutes. Conclusions: These results indicate that free radical-mediated lipid peroxidation occurs at reperfusion of warm ischemic viscera in the clinical setting of aortic repair. This observation supports the hypothesis that substantial lipid peroxidation occurs when tissues are subjected to cold or warm ischemia followed by reperfusion.

UR - http://www.scopus.com/inward/record.url?scp=0028299108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028299108&partnerID=8YFLogxK

M3 - Article

C2 - 8126860

AN - SCOPUS:0028299108

VL - 19

SP - 473

EP - 477

JO - Journal of Vascular Surgery

JF - Journal of Vascular Surgery

SN - 0741-5214

IS - 3

ER -