Visceral chemical nociception in mice lacking μ-opioid receptors: Effects of morphine, SNC80 and U-50,488

Ichiro Sora, Xiao Fei Li, Masahiko Funada, Stephen Kinsey, George R. Uhl

Research output: Contribution to journalArticle

Abstract

Writhing responses to intraperitoneal acetic acid administration and their modulation by μ-, κ- and δ-opioid receptor agonists were compared in wild-type and μ-opioid receptor knockout mice. Unpretreated homozygous knockout mice displayed less writhing than wild-type mice. U-50,488 [trans-3,4-dichloro-N-methyl-N-[2-(1-pyrolidinyl)cyclohexyl]-benzeneacetamide]) reduced writhing responses in wild-type and knockouts. Morphine and SNC80 [(+)-4-[9-α-R)-α-(2S,5RO-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] were effective in wild-type mice but ineffective in knockouts. μ-opioid receptors appear to play important roles in responses to this visceral nociceptive stimulus and its modulation by μ- and δ-opioid receptor agonists. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
JournalEuropean Journal of Pharmacology
Volume366
Issue number2-3
DOIs
StatePublished - Feb 5 1999

Keywords

  • μ-Opioid receptor knockout mouse
  • Visceral pain
  • Writhing test

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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